Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3764065..3764721 Replicon chromosome
Accession NZ_CP127881
Organism Serratia marcescens strain ELP1.10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QRD25_RS17975 Protein ID WP_004941566.1
Coordinates 3764065..3764454 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag QRD25_RS17980 Protein ID WP_004941563.1
Coordinates 3764458..3764721 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD25_RS17960 (QRD25_17965) 3760532..3761962 + 1431 WP_286093508.1 multidrug transporter subunit MdtD -
QRD25_RS17965 (QRD25_17970) 3761959..3763341 + 1383 WP_004941570.1 two-component system sensor histidine kinase BaeS -
QRD25_RS17970 (QRD25_17975) 3763341..3764057 + 717 WP_004941568.1 two-component system response regulator BaeR -
QRD25_RS17975 (QRD25_17980) 3764065..3764454 - 390 WP_004941566.1 type II toxin-antitoxin system VapC family toxin Toxin
QRD25_RS17980 (QRD25_17985) 3764458..3764721 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QRD25_RS17985 (QRD25_17990) 3765059..3765397 + 339 WP_004941561.1 YegP family protein -
QRD25_RS17990 (QRD25_17995) 3765576..3766928 + 1353 WP_004941558.1 tRNA 5-hydroxyuridine modification protein YegQ -
QRD25_RS17995 (QRD25_18000) 3767396..3768301 + 906 WP_015378742.1 lipid kinase YegS -
QRD25_RS18000 (QRD25_18005) 3768470..3769684 + 1215 WP_015378743.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14384.61 Da        Isoelectric Point: 8.4983

>T284341 WP_004941566.1 NZ_CP127881:c3764454-3764065 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKVMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT284341 WP_004941563.1 NZ_CP127881:c3764721-3764458 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References