Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3667286..3667848 Replicon chromosome
Accession NZ_CP127881
Organism Serratia marcescens strain ELP1.10

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag QRD25_RS17550 Protein ID WP_286093499.1
Coordinates 3667286..3667642 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag QRD25_RS17555 Protein ID WP_004936539.1
Coordinates 3667639..3667848 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD25_RS17530 (QRD25_17535) 3663022..3663819 - 798 WP_197753423.1 TonB family protein -
QRD25_RS17535 (QRD25_17540) 3663922..3664761 - 840 WP_131165142.1 ChaN family lipoprotein -
QRD25_RS17540 (QRD25_17545) 3664939..3666348 + 1410 WP_033639696.1 S-methylmethionine permease -
QRD25_RS17545 (QRD25_17550) 3666338..3667276 + 939 WP_049188795.1 homocysteine S-methyltransferase -
QRD25_RS17550 (QRD25_17555) 3667286..3667642 - 357 WP_286093499.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QRD25_RS17555 (QRD25_17560) 3667639..3667848 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
QRD25_RS17560 (QRD25_17565) 3667958..3670237 - 2280 WP_004936542.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
QRD25_RS17565 (QRD25_17570) 3670452..3670625 - 174 WP_004936544.1 hypothetical protein -
QRD25_RS17570 (QRD25_17575) 3670606..3670986 - 381 WP_044030723.1 DUF2570 family protein -
QRD25_RS17575 (QRD25_17580) 3670983..3671384 - 402 WP_021505638.1 M15 family metallopeptidase -
QRD25_RS17580 (QRD25_17585) 3671374..3671700 - 327 WP_033643982.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13228.95 Da        Isoelectric Point: 4.6212

>T284340 WP_286093499.1 NZ_CP127881:c3667642-3667286 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQDGSKVEAVANRELNAYHYENVTDVYRLAALYLIAISHGHIFLDDNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEKLRRLTE

Download         Length: 357 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT284340 WP_004936539.1 NZ_CP127881:c3667848-3667639 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References