28434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 330593..331250 Replicon chromosome
Accession NC_018938
Organism Helicobacter pylori Rif2

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag C730_RS01605 Protein ID WP_000271050.1
Coordinates 330593..330877 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O25085
Locus tag C730_RS01610 Protein ID WP_001134066.1
Coordinates 330858..331250 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C730_RS01580 325795..326673 + 879 WP_000850703.1 carbon-nitrogen hydrolase family protein -
C730_RS01585 326686..327567 + 882 WP_001040419.1 polysaccharide deacetylase -
C730_RS01590 327613..327981 + 369 WP_000337920.1 hypothetical protein -
C730_RS01595 327981..328946 + 966 WP_001124369.1 GTP-binding protein -
C730_RS01600 328952..330097 - 1146 WP_001263616.1 YbfB/YjiJ family MFS transporter -
C730_RS01605 330593..330877 - 285 WP_000271050.1 endoribonuclease VapD Toxin
C730_RS01610 330858..331250 - 393 WP_001134066.1 hypothetical protein Antitoxin
C730_RS01620 331859..334096 - 2238 WP_000716253.1 outer membrane beta-barrel protein -
C730_RS01625 334393..335148 - 756 WP_000934548.1 HugZ family heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T28434 WP_000271050.1 NC_018938:c330877-330593 [Helicobacter pylori Rif2]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T28434 NC_018938:c330877-330593 [Helicobacter pylori Rif2]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTGGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15304.38 Da        Isoelectric Point: 7.1101

>AT28434 WP_001134066.1 NC_018938:c331250-330858 [Helicobacter pylori Rif2]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRISFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIETQQAMRDALNGINLTQIDSLDDFTNELKRENSKGFENVCFSV

Download         Length: 393 bp

>AT28434 NC_018938:c331250-330858 [Helicobacter pylori Rif2]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAATTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGTCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGAATTAATCTCACTCAAATTGATAG
TTTAGATGATTTTACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y3E322

References