Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 200552..201188 Replicon chromosome
Accession NZ_CP127874
Organism Priestia megaterium strain ELP1.24a

Toxin (Protein)


Gene name mazF Uniprot ID D5DWT4
Locus tag QRD24_RS01130 Protein ID WP_013055004.1
Coordinates 200838..201188 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5DWT3
Locus tag QRD24_RS01125 Protein ID WP_013055003.1
Coordinates 200552..200833 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD24_RS01100 (QRD24_01100) 195918..196889 + 972 WP_028410443.1 UV DNA damage repair endonuclease UvsE -
QRD24_RS01105 (QRD24_01105) 196898..197500 - 603 WP_098433927.1 rhomboid family intramembrane serine protease -
QRD24_RS01110 (QRD24_01110) 197565..197930 + 366 WP_025753519.1 holo-ACP synthase -
QRD24_RS01115 (QRD24_01115) 197989..199047 + 1059 WP_013055001.1 outer membrane lipoprotein carrier protein LolA -
QRD24_RS01120 (QRD24_01120) 199161..200351 + 1191 WP_221841476.1 alanine racemase -
QRD24_RS01125 (QRD24_01125) 200552..200833 + 282 WP_013055003.1 hypothetical protein Antitoxin
QRD24_RS01130 (QRD24_01130) 200838..201188 + 351 WP_013055004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRD24_RS01135 (QRD24_01135) 201346..202182 + 837 WP_013055005.1 RsbT co-antagonist protein RsbRA -
QRD24_RS01140 (QRD24_01140) 202185..202541 + 357 WP_013055006.1 STAS domain-containing protein -
QRD24_RS01145 (QRD24_01145) 202545..202946 + 402 WP_013055007.1 anti-sigma regulatory factor -
QRD24_RS01150 (QRD24_01150) 202960..203970 + 1011 WP_013055008.1 PP2C family protein-serine/threonine phosphatase -
QRD24_RS01155 (QRD24_01155) 204030..204362 + 333 WP_013055009.1 anti-sigma factor antagonist -
QRD24_RS01160 (QRD24_01160) 204359..204844 + 486 WP_025753516.1 anti-sigma B factor RsbW -
QRD24_RS01165 (QRD24_01165) 204810..205604 + 795 WP_013055011.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.96 Da        Isoelectric Point: 4.8781

>T284330 WP_013055004.1 NZ_CP127874:200838-201188 [Priestia megaterium]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10691.22 Da        Isoelectric Point: 8.5339

>AT284330 WP_013055003.1 NZ_CP127874:200552-200833 [Priestia megaterium]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6AMB9

References