Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4762270..4762898 Replicon chromosome
Accession NZ_CP127872
Organism Pseudomonas asiatica strain RYYT.1b

Toxin (Protein)


Gene name hicA Uniprot ID V9X276
Locus tag QQ994_RS21485 Protein ID WP_025340378.1
Coordinates 4762716..4762898 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1L5PZ99
Locus tag QQ994_RS21480 Protein ID WP_038408384.1
Coordinates 4762270..4762695 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ994_RS21470 (QQ994_21470) 4758341..4759681 + 1341 WP_075046131.1 PLP-dependent aminotransferase family protein -
QQ994_RS21475 (QQ994_21475) 4759785..4762226 + 2442 WP_075046132.1 penicillin acylase family protein -
QQ994_RS21480 (QQ994_21480) 4762270..4762695 - 426 WP_038408384.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QQ994_RS21485 (QQ994_21485) 4762716..4762898 - 183 WP_025340378.1 type II toxin-antitoxin system HicA family toxin Toxin
QQ994_RS21490 (QQ994_21490) 4763105..4764121 + 1017 WP_085706037.1 ligase-associated DNA damage response exonuclease -
QQ994_RS21495 (QQ994_21495) 4764118..4765776 + 1659 WP_075046134.1 ATP-dependent DNA ligase -
QQ994_RS21500 (QQ994_21500) 4765999..4767114 + 1116 WP_075046135.1 M14 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6895.01 Da        Isoelectric Point: 11.1658

>T284317 WP_025340378.1 NZ_CP127872:c4762898-4762716 [Pseudomonas asiatica]
MKYSEFRRWLRGQGATFVAAKGSHFKVYLGNRQTIFPDHGAKEISEGLRRKILKDLGLKS

Download         Length: 183 bp

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15426.84 Da        Isoelectric Point: 4.7494

>AT284317 WP_038408384.1 NZ_CP127872:c4762695-4762270 [Pseudomonas asiatica]
MVFEYPVVVHLEDGSVWVSCPDVPEMACAGDTSEEALFDAVDALESALSFYVDQKIAIPLPATPTEGQPVVRLPALTAAK
AALWNTMVAQKISKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELSVVAV

Download         Length: 426 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V9X276

Antitoxin

Source ID Structure
AlphaFold DB A0A1L5PZ99

References