Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 842783..843312 Replicon chromosome
Accession NZ_CP127869
Organism Staphylococcus epidermidis strain NG02

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag QQ988_RS03935 Protein ID WP_001829891.1
Coordinates 842950..843312 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag QQ988_RS03930 Protein ID WP_001829931.1
Coordinates 842783..842953 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ988_RS03905 (QQ988_03905) 838607..839086 + 480 WP_002494210.1 PH domain-containing protein -
QQ988_RS03910 (QQ988_03910) 839079..840584 + 1506 WP_060556106.1 PH domain-containing protein -
QQ988_RS03915 (QQ988_03915) 840571..841080 + 510 WP_002494208.1 PH domain-containing protein -
QQ988_RS03920 (QQ988_03920) 841128..841481 + 354 WP_001829915.1 holo-ACP synthase -
QQ988_RS03925 (QQ988_03925) 841548..842696 + 1149 WP_002494207.1 alanine racemase -
QQ988_RS03930 (QQ988_03930) 842783..842953 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QQ988_RS03935 (QQ988_03935) 842950..843312 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QQ988_RS03940 (QQ988_03940) 843657..844658 + 1002 WP_002494206.1 PP2C family protein-serine/threonine phosphatase -
QQ988_RS03945 (QQ988_03945) 844758..845084 + 327 WP_001829952.1 anti-sigma factor antagonist -
QQ988_RS03950 (QQ988_03950) 845086..845565 + 480 WP_002474646.1 anti-sigma B factor RsbW -
QQ988_RS03955 (QQ988_03955) 845540..846310 + 771 WP_002474636.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T284306 WP_001829891.1 NZ_CP127869:842950-843312 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT284306 WP_001829931.1 NZ_CP127869:842783-842953 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References