Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 831598..832107 Replicon chromosome
Accession NZ_CP127869
Organism Staphylococcus epidermidis strain NG02

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag QQ988_RS03875 Protein ID WP_002494211.1
Coordinates 831904..832107 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag QQ988_RS03870 Protein ID WP_001829893.1
Coordinates 831598..831891 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ988_RS03845 (QQ988_03845) 826606..827394 + 789 WP_002494215.1 hydroxyethylthiazole kinase -
QQ988_RS03850 (QQ988_03850) 827400..828038 + 639 WP_032603839.1 thiamine phosphate synthase -
QQ988_RS03855 (QQ988_03855) 828127..828999 + 873 WP_002458703.1 membrane protein insertase YidC -
QQ988_RS03860 (QQ988_03860) 829105..829758 - 654 WP_002494213.1 HD domain-containing protein -
QQ988_RS03865 (QQ988_03865) 829940..831424 - 1485 WP_002494212.1 cardiolipin synthase -
QQ988_RS03870 (QQ988_03870) 831598..831891 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
QQ988_RS03875 (QQ988_03875) 831904..832107 + 204 WP_002494211.1 hypothetical protein Toxin
QQ988_RS03880 (QQ988_03880) 832250..832387 + 138 WP_001829949.1 Lmo0850 family protein -
QQ988_RS03885 (QQ988_03885) 832486..833697 - 1212 WP_002474606.1 FtsW/RodA/SpoVE family cell cycle protein -
QQ988_RS03890 (QQ988_03890) 834088..835161 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
QQ988_RS03895 (QQ988_03895) 835173..836528 + 1356 WP_002494890.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7785.00 Da        Isoelectric Point: 6.4524

>T284305 WP_002494211.1 NZ_CP127869:831904-832107 [Staphylococcus epidermidis]
MKKGLIHVSGIKTTEQAKQLKDHLSKMIGINCVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 204 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT284305 WP_001829893.1 NZ_CP127869:831598-831891 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References