Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 61782..62425 Replicon plasmid pMB7671_2
Accession NZ_CP127850
Organism Escherichia coli strain MB7671

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag PJZ59_RS23590 Protein ID WP_001044768.1
Coordinates 61782..62198 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag PJZ59_RS23595 Protein ID WP_001261287.1
Coordinates 62195..62425 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJZ59_RS23575 (PJZ59_23575) 57086..58018 - 933 WP_000991832.1 S-4TM family putative pore-forming effector -
PJZ59_RS23580 (PJZ59_23580) 58022..59017 - 996 WP_000246636.1 hypothetical protein -
PJZ59_RS23585 (PJZ59_23585) 59482..61620 + 2139 WP_000350635.1 AAA family ATPase -
PJZ59_RS23590 (PJZ59_23590) 61782..62198 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
PJZ59_RS23595 (PJZ59_23595) 62195..62425 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PJZ59_RS23600 (PJZ59_23600) 62732..65851 + 3120 WP_023909028.1 hypothetical protein -
PJZ59_RS23605 (PJZ59_23605) 66114..67247 + 1134 WP_000545983.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / mph(A) / sul2 / aph(3'')-Ib / aph(6)-Id / tet(B) - 1..70343 70343
- flank IS/Tn - - 56446..56949 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T284293 WP_001044768.1 NZ_CP127850:c62198-61782 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT284293 WP_001261287.1 NZ_CP127850:c62425-62195 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References