Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2056..2615 Replicon plasmid pMB7671_1
Accession NZ_CP127849
Organism Escherichia coli strain MB7671

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag PJZ59_RS22620 Protein ID WP_000421259.1
Coordinates 2340..2615 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag PJZ59_RS22615 Protein ID WP_001178087.1
Coordinates 2056..2340 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJZ59_RS22610 (PJZ59_22610) 279..1157 + 879 WP_000729439.1 incFII family plasmid replication initiator RepA -
PJZ59_RS22615 (PJZ59_22615) 2056..2340 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
PJZ59_RS22620 (PJZ59_22620) 2340..2615 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PJZ59_RS22625 (PJZ59_22625) 2721..2918 + 198 Protein_3 hypothetical protein -
PJZ59_RS22630 (PJZ59_22630) 3187..3453 - 267 WP_000627832.1 hypothetical protein -
PJZ59_RS22635 (PJZ59_22635) 3453..3671 - 219 Protein_5 hypothetical protein -
PJZ59_RS22640 (PJZ59_22640) 3699..4301 - 603 WP_000521606.1 ProQ/FINO family protein -
PJZ59_RS22645 (PJZ59_22645) 4477..5529 - 1053 WP_000655519.1 hypothetical protein -
PJZ59_RS22650 (PJZ59_22650) 5742..6332 - 591 WP_001401589.1 hypothetical protein -
PJZ59_RS22655 (PJZ59_22655) 6332..6586 - 255 WP_000343106.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / qacE / aadA5 - 1..108804 108804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T284290 WP_000421259.1 NZ_CP127849:2340-2615 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT284290 WP_001178087.1 NZ_CP127849:2056-2340 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References