Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1604446..1605058 Replicon chromosome
Accession NC_018936
Organism Streptococcus pyogenes A20

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag A20_RS08135 Protein ID WP_010922665.1
Coordinates 1604723..1605058 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag A20_RS08130 Protein ID WP_002988079.1
Coordinates 1604446..1604733 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A20_RS08105 1599623..1600606 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
A20_RS08110 1600610..1601539 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
A20_RS08115 1601587..1602102 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
A20_RS08120 1602137..1602565 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
A20_RS08125 1603012..1603785 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
A20_RS08130 1604446..1604733 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
A20_RS08135 1604723..1605058 + 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A20_RS09875 1605210..1605680 + 471 Protein_1539 integrase -
A20_RS09585 1605726..1606163 + 438 WP_076639988.1 site-specific integrase -
A20_RS08145 1606283..1606675 - 393 WP_002982716.1 30S ribosomal protein S9 -
A20_RS08150 1606696..1607142 - 447 WP_002982710.1 50S ribosomal protein L13 -
A20_RS08155 1607360..1607566 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
A20_RS08160 1607563..1608069 - 507 WP_002988070.1 hypothetical protein -
A20_RS08165 1608205..1609065 - 861 WP_002982687.1 DegV family protein -
A20_RS08170 1609162..1609680 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T28429 WP_010922665.1 NC_018936:1604723-1605058 [Streptococcus pyogenes A20]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T28429 NC_018936:1604723-1605058 [Streptococcus pyogenes A20]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT28429 WP_002988079.1 NC_018936:1604446-1604733 [Streptococcus pyogenes A20]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT28429 NC_018936:1604446-1604733 [Streptococcus pyogenes A20]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References