Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4182672..4183169 Replicon chromosome
Accession NZ_CP127848
Organism Escherichia coli strain MB7671

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PJZ59_RS20330 Protein ID WP_001173343.1
Coordinates 4182672..4182845 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag PJZ59_RS20335 Protein ID WP_001425728.1
Coordinates 4182873..4183169 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJZ59_RS20320 (4179342) 4179342..4180799 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
PJZ59_RS20325 (4181036) 4181036..4182553 + 1518 WP_001295074.1 lysine--tRNA ligase -
PJZ59_RS20330 (4182672) 4182672..4182845 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PJZ59_RS20335 (4182873) 4182873..4183169 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PJZ59_RS20340 (4183396) 4183396..4183668 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PJZ59_RS20345 (4183680) 4183680..4183910 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PJZ59_RS20350 (4184091) 4184091..4185722 + 1632 WP_001216487.1 sensor histidine kinase -
PJZ59_RS20355 (4185719) 4185719..4186438 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T284289 WP_001173343.1 NZ_CP127848:c4182845-4182672 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT284289 WP_001425728.1 NZ_CP127848:c4183169-4182873 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References