Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3450477..3451095 Replicon chromosome
Accession NZ_CP127848
Organism Escherichia coli strain MB7671

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PJZ59_RS16775 Protein ID WP_001291435.1
Coordinates 3450877..3451095 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PJZ59_RS16770 Protein ID WP_000344800.1
Coordinates 3450477..3450851 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJZ59_RS16760 (3445566) 3445566..3446759 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PJZ59_RS16765 (3446782) 3446782..3449931 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PJZ59_RS16770 (3450477) 3450477..3450851 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PJZ59_RS16775 (3450877) 3450877..3451095 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PJZ59_RS16780 (3451267) 3451267..3451818 + 552 WP_000102568.1 maltose O-acetyltransferase -
PJZ59_RS16785 (3451934) 3451934..3452404 + 471 WP_000136192.1 YlaC family protein -
PJZ59_RS16790 (3452568) 3452568..3454118 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PJZ59_RS16795 (3454160) 3454160..3454513 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PJZ59_RS16805 (3454892) 3454892..3455203 + 312 WP_000409911.1 MGMT family protein -
PJZ59_RS16810 (3455234) 3455234..3455806 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T284287 WP_001291435.1 NZ_CP127848:3450877-3451095 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT284287 WP_000344800.1 NZ_CP127848:3450477-3450851 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References