Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1317642..1318267 Replicon chromosome
Accession NZ_CP127848
Organism Escherichia coli strain MB7671

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PJZ59_RS06445 Protein ID WP_000911330.1
Coordinates 1317869..1318267 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PJZ59_RS06440 Protein ID WP_000450524.1
Coordinates 1317642..1317869 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJZ59_RS06415 (1313445) 1313445..1313915 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PJZ59_RS06420 (1313915) 1313915..1314487 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PJZ59_RS06425 (1314633) 1314633..1315511 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PJZ59_RS06430 (1315528) 1315528..1316562 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PJZ59_RS06435 (1316775) 1316775..1317488 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PJZ59_RS06440 (1317642) 1317642..1317869 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PJZ59_RS06445 (1317869) 1317869..1318267 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PJZ59_RS06450 (1318414) 1318414..1319277 + 864 WP_001267507.1 neutral zinc metallopeptidase -
PJZ59_RS06455 (1319292) 1319292..1321307 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
PJZ59_RS06460 (1321381) 1321381..1322079 + 699 WP_000679823.1 esterase -
PJZ59_RS06465 (1322189) 1322189..1322389 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T284282 WP_000911330.1 NZ_CP127848:1317869-1318267 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT284282 WP_000450524.1 NZ_CP127848:1317642-1317869 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References