Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4763889..4764405 Replicon chromosome
Accession NZ_CP127839
Organism Klebsiella pneumoniae RYC492

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag QRF73_RS23080 Protein ID WP_004894697.1
Coordinates 4763889..4764173 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QRF73_RS23085 Protein ID WP_002886901.1
Coordinates 4764163..4764405 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF73_RS23055 (QRF73_23050) 4759284..4759547 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
QRF73_RS23060 (QRF73_23055) 4759677..4759850 + 174 WP_002886906.1 hypothetical protein -
QRF73_RS23065 (QRF73_23060) 4759853..4760596 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
QRF73_RS23070 (QRF73_23065) 4760954..4763092 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
QRF73_RS23075 (QRF73_23070) 4763421..4763885 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QRF73_RS23080 (QRF73_23075) 4763889..4764173 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRF73_RS23085 (QRF73_23080) 4764163..4764405 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QRF73_RS23090 (QRF73_23085) 4764483..4766393 - 1911 WP_004894700.1 PRD domain-containing protein -
QRF73_RS23095 (QRF73_23090) 4766416..4767570 - 1155 WP_004178372.1 lactonase family protein -
QRF73_RS23100 (QRF73_23095) 4767637..4768377 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T284270 WP_004894697.1 NZ_CP127839:c4764173-4763889 [Klebsiella pneumoniae RYC492]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT284270 WP_002886901.1 NZ_CP127839:c4764405-4764163 [Klebsiella pneumoniae RYC492]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References