Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2627608..2629196 Replicon chromosome
Accession NZ_CP127839
Organism Klebsiella pneumoniae RYC492

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag QRF73_RS12885 Protein ID WP_004892016.1
Coordinates 2627608..2628930 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QRF73_RS12890 Protein ID WP_004176198.1
Coordinates 2628930..2629196 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF73_RS12870 (QRF73_12870) 2622664..2625165 + 2502 WP_004892009.1 fimbria/pilus outer membrane usher protein -
QRF73_RS12875 (QRF73_12875) 2625153..2626157 + 1005 WP_004892012.1 fimbrial protein -
QRF73_RS12880 (QRF73_12880) 2626299..2627591 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QRF73_RS12885 (QRF73_12885) 2627608..2628930 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
QRF73_RS12890 (QRF73_12890) 2628930..2629196 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QRF73_RS12895 (QRF73_12895) 2629461..2629787 - 327 WP_004892019.1 hydroxyisourate hydrolase -
QRF73_RS12900 (QRF73_12900) 2629784..2630284 - 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QRF73_RS12905 (QRF73_12905) 2630262..2631641 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
QRF73_RS12910 (QRF73_12910) 2631987..2633141 + 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
QRF73_RS12915 (QRF73_12915) 2633122..2634045 - 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2424294..2664679 240385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T284265 WP_004892016.1 NZ_CP127839:c2628930-2627608 [Klebsiella pneumoniae RYC492]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT284265 WP_004176198.1 NZ_CP127839:c2629196-2628930 [Klebsiella pneumoniae RYC492]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References