Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 781077..781734 Replicon chromosome
Accession NZ_CP127839
Organism Klebsiella pneumoniae RYC492

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QRF73_RS03880 Protein ID WP_002916310.1
Coordinates 781324..781734 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QRF73_RS03875 Protein ID WP_002916312.1
Coordinates 781077..781343 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF73_RS03850 (QRF73_03850) 776095..777528 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QRF73_RS03855 (QRF73_03855) 777785..778513 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QRF73_RS03860 (QRF73_03860) 778563..778874 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QRF73_RS03865 (QRF73_03865) 779038..779697 + 660 WP_004889817.1 hemolysin III family protein -
QRF73_RS03870 (QRF73_03870) 779848..780831 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QRF73_RS03875 (QRF73_03875) 781077..781343 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QRF73_RS03880 (QRF73_03880) 781324..781734 + 411 WP_002916310.1 protein YgfX Toxin
QRF73_RS03885 (QRF73_03885) 781741..782262 - 522 WP_004144730.1 flavodoxin FldB -
QRF73_RS03890 (QRF73_03890) 782363..783259 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QRF73_RS03895 (QRF73_03895) 783282..783995 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRF73_RS03900 (QRF73_03900) 784001..785734 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T284260 WP_002916310.1 NZ_CP127839:781324-781734 [Klebsiella pneumoniae RYC492]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT284260 WP_002916312.1 NZ_CP127839:781077-781343 [Klebsiella pneumoniae RYC492]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References