Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1234627..1235544 Replicon chromosome
Accession NZ_CP127834
Organism Bacillus velezensis strain Ag109

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NSY31_RS06470 Protein ID WP_032866111.1
Coordinates 1234798..1235544 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NSY31_RS06465 Protein ID WP_003154807.1
Coordinates 1234627..1234797 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NSY31_RS06430 (NSY31_06430) 1229852..1231483 + 1632 WP_060561803.1 pyocin knob domain-containing protein -
NSY31_RS06435 (NSY31_06435) 1231496..1231867 + 372 WP_060561802.1 XkdW family protein -
NSY31_RS06440 (NSY31_06440) 1231872..1232069 + 198 WP_059367156.1 XkdX family protein -
NSY31_RS06445 (NSY31_06445) 1232126..1232886 + 761 Protein_1208 phage portal protein -
NSY31_RS06450 (NSY31_06450) 1232938..1233201 + 264 WP_098081338.1 hemolysin XhlA family protein -
NSY31_RS06455 (NSY31_06455) 1233215..1233478 + 264 WP_003154813.1 phage holin -
NSY31_RS06460 (NSY31_06460) 1233492..1234370 + 879 WP_043021264.1 N-acetylmuramoyl-L-alanine amidase -
NSY31_RS06465 (NSY31_06465) 1234627..1234797 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NSY31_RS06470 (NSY31_06470) 1234798..1235544 - 747 WP_032866111.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NSY31_RS06475 (NSY31_06475) 1235649..1236647 - 999 WP_007407255.1 inorganic phosphate transporter -
NSY31_RS06480 (NSY31_06480) 1236660..1237277 - 618 WP_003154804.1 DUF47 domain-containing protein -
NSY31_RS06485 (NSY31_06485) 1237563..1238879 - 1317 WP_007610842.1 amino acid permease -
NSY31_RS06490 (NSY31_06490) 1239202..1240152 + 951 WP_098081339.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29095.60 Da        Isoelectric Point: 4.7755

>T284256 WP_032866111.1 NZ_CP127834:c1235544-1234798 [Bacillus velezensis]
MLMFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT284256 WP_003154807.1 NZ_CP127834:c1234797-1234627 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References