Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 866887..867523 Replicon chromosome
Accession NZ_CP127833
Organism Bacillus mojavensis strain KRS009

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QLQ02_RS04395 Protein ID WP_003156187.1
Coordinates 866887..867237 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QLQ02_RS04400 Protein ID WP_003225183.1
Coordinates 867242..867523 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ02_RS04355 (861929) 861929..862528 - 600 WP_010333121.1 phosphoserine phosphatase RsbX -
QLQ02_RS04360 (862528) 862528..863316 - 789 WP_010333120.1 RNA polymerase sigma factor SigB -
QLQ02_RS04365 (863282) 863282..863764 - 483 WP_010333119.1 anti-sigma B factor RsbW -
QLQ02_RS04370 (863761) 863761..864090 - 330 WP_268444340.1 anti-sigma factor antagonist RsbV -
QLQ02_RS04375 (864152) 864152..865159 - 1008 WP_010333117.1 phosphoserine phosphatase RsbU -
QLQ02_RS04380 (865171) 865171..865572 - 402 WP_010333116.1 serine/threonine-protein kinase RsbT -
QLQ02_RS04385 (865576) 865576..865941 - 366 WP_010333115.1 RsbT antagonist protein RsbS -
QLQ02_RS04390 (865946) 865946..866770 - 825 WP_081720860.1 RsbT co-antagonist protein RsbRA -
QLQ02_RS04395 (866887) 866887..867237 - 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QLQ02_RS04400 (867242) 867242..867523 - 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QLQ02_RS04405 (867641) 867641..868810 - 1170 WP_168746988.1 alanine racemase -
QLQ02_RS04410 (868927) 868927..869943 - 1017 WP_081720864.1 outer membrane lipoprotein carrier protein LolA -
QLQ02_RS04415 (870109) 870109..870474 - 366 WP_010333111.1 holo-ACP synthase -
QLQ02_RS04420 (870569) 870569..871168 + 600 WP_286059014.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T284254 WP_003156187.1 NZ_CP127833:c867237-866887 [Bacillus mojavensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT284254 WP_003225183.1 NZ_CP127833:c867523-867242 [Bacillus mojavensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References