Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 116600..118132 Replicon chromosome
Accession NZ_CP127406
Organism Stenotrophomonas sp. As-14

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QP482_RS00500 Protein ID WP_205407028.1
Coordinates 116600..117922 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QP482_RS00505 Protein ID WP_223880281.1
Coordinates 117926..118132 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP482_RS00485 112009..113643 - 1635 WP_205405403.1 TldD/PmbA family protein -
QP482_RS00490 113671..115302 - 1632 WP_205405402.1 TldD/PmbA family protein -
QP482_RS00495 115985..116599 + 615 WP_205407029.1 DUF938 domain-containing protein -
QP482_RS00500 116600..117922 - 1323 WP_205407028.1 type II toxin-antitoxin system HipA family toxin Toxin
QP482_RS00505 117926..118132 - 207 WP_223880281.1 helix-turn-helix transcriptional regulator Antitoxin
QP482_RS00510 118338..122024 - 3687 WP_205407027.1 indolepyruvate ferredoxin oxidoreductase family protein -
QP482_RS00515 122196..122831 + 636 WP_180164639.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(2-53)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48797.47 Da        Isoelectric Point: 6.6886

>T284249 WP_205407028.1 NZ_CP127406:c117922-116600 [Stenotrophomonas sp. As-14]
MGTLRVWMNGVEVALWDDARNRASRLSYLSQWIGSTQSRPLSLSLPLLPDGESHQGQVVNDYFDNLLPDNVTIRNRIRDR
FATRSSNTFDLLEAIGRDCVGAVQLLPHSRTPDAIQRITFEPLNDSGVAEVLRQVTTSALPGTSSSDDAFRISIAGAQEK
TGLLLHDGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLAAFGIPVADTQMGRFEDQGALIVERFDRR
LAADRVWWLRLPQEDMCQVFGLPAARKYESDGGPGIVAIMDLLRQSEQPEDRATFFKTQILFWMLAATDGHAKNFSVHID
AGGRFRLTPVYDVLSVYPILGRGPNQLDPHNAQLAMAVEGKNRHRKLHLVRRRHWNETARACGVADGAEPWIEALIASVE
PAIEHVTRQLPSGFPSTVSEPVFKGLRAAATRLSSMAPDA

Download         Length: 1323 bp

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7671.70 Da        Isoelectric Point: 11.8979

>AT284249 WP_223880281.1 NZ_CP127406:c118132-117926 [Stenotrophomonas sp. As-14]
MRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRVWAVLGLEISLQQRSPRENTSTSEW

Download         Length: 207 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References