Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 164837..166420 Replicon chromosome
Accession NZ_CP127405
Organism Stenotrophomonas sp. As-7

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QP457_RS00705 Protein ID WP_205407028.1
Coordinates 164837..166159 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QP457_RS00710 Protein ID WP_089241740.1
Coordinates 166163..166420 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP457_RS00690 160246..161880 - 1635 WP_205405403.1 TldD/PmbA family protein -
QP457_RS00695 161908..163539 - 1632 WP_205405402.1 TldD/PmbA family protein -
QP457_RS00700 164222..164836 + 615 WP_205407029.1 DUF938 domain-containing protein -
QP457_RS00705 164837..166159 - 1323 WP_205407028.1 type II toxin-antitoxin system HipA family toxin Toxin
QP457_RS00710 166163..166420 - 258 WP_089241740.1 helix-turn-helix transcriptional regulator Antitoxin
QP457_RS00715 166575..170261 - 3687 WP_205407027.1 indolepyruvate ferredoxin oxidoreductase family protein -
QP457_RS00720 170433..171068 + 636 WP_180164639.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48797.47 Da        Isoelectric Point: 6.6886

>T284248 WP_205407028.1 NZ_CP127405:c166159-164837 [Stenotrophomonas sp. As-7]
MGTLRVWMNGVEVALWDDARNRASRLSYLSQWIGSTQSRPLSLSLPLLPDGESHQGQVVNDYFDNLLPDNVTIRNRIRDR
FATRSSNTFDLLEAIGRDCVGAVQLLPHSRTPDAIQRITFEPLNDSGVAEVLRQVTTSALPGTSSSDDAFRISIAGAQEK
TGLLLHDGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLAAFGIPVADTQMGRFEDQGALIVERFDRR
LAADRVWWLRLPQEDMCQVFGLPAARKYESDGGPGIVAIMDLLRQSEQPEDRATFFKTQILFWMLAATDGHAKNFSVHID
AGGRFRLTPVYDVLSVYPILGRGPNQLDPHNAQLAMAVEGKNRHRKLHLVRRRHWNETARACGVADGAEPWIEALIASVE
PAIEHVTRQLPSGFPSTVSEPVFKGLRAAATRLSSMAPDA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9610.97 Da        Isoelectric Point: 12.0228

>AT284248 WP_089241740.1 NZ_CP127405:c166420-166163 [Stenotrophomonas sp. As-7]
MDRPPHTVRTPQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRVWAVLGLEISLQQRSPRENT
STSEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References