Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2683749..2684380 Replicon chromosome
Accession NZ_CP127390
Organism Propionimicrobium sp. PCR01-08-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QQ658_RS12445 Protein ID WP_286025156.1
Coordinates 2683749..2684126 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QQ658_RS12450 Protein ID WP_286025157.1
Coordinates 2684123..2684380 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ658_RS12420 (QQ658_12420) 2678984..2680495 - 1512 WP_286025151.1 methylmalonyl-CoA carboxytransferase subunit 5S -
QQ658_RS12425 (QQ658_12425) 2680824..2682722 + 1899 WP_286025152.1 asparagine synthase (glutamine-hydrolyzing) -
QQ658_RS12430 (QQ658_12430) 2682816..2683211 - 396 WP_286025153.1 type II toxin-antitoxin system VapC family toxin -
QQ658_RS12435 (QQ658_12435) 2683208..2683432 - 225 WP_286025154.1 toxin-antitoxin system, antitoxin component -
QQ658_RS12440 (QQ658_12440) 2683528..2683686 - 159 WP_286025155.1 hypothetical protein -
QQ658_RS12445 (QQ658_12445) 2683749..2684126 - 378 WP_286025156.1 type II toxin-antitoxin system VapC family toxin Toxin
QQ658_RS12450 (QQ658_12450) 2684123..2684380 - 258 WP_286025157.1 CopG family transcriptional regulator Antitoxin
QQ658_RS12455 (QQ658_12455) 2684586..2685224 + 639 WP_286025158.1 helix-turn-helix domain-containing protein -
QQ658_RS12460 (QQ658_12460) 2685217..2685870 + 654 WP_286025159.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
QQ658_RS12465 (QQ658_12465) 2685896..2687065 - 1170 WP_286025160.1 GAF domain-containing protein -
QQ658_RS12470 (QQ658_12470) 2687347..2688339 + 993 WP_286025161.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -
QQ658_RS12475 (QQ658_12475) 2688355..2689371 + 1017 WP_286025162.1 alpha-ketoacid dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13441.56 Da        Isoelectric Point: 6.0724

>T284242 WP_286025156.1 NZ_CP127390:c2684126-2683749 [Propionimicrobium sp. PCR01-08-3]
MSVLIDTSVLIDVLRGHRPAAVVLKTARMNGLLHASEITRLEVLAGMRPSEETSTRALLGALTWHSVDEEVAEIAGELGR
RWLPGNRGIDSADLAIAATATLLDAPILTCNVKHFPMFNGLTAPY

Download         Length: 378 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9301.27 Da        Isoelectric Point: 4.8018

>AT284242 WP_286025157.1 NZ_CP127390:c2684380-2684123 [Propionimicrobium sp. PCR01-08-3]
MMRTQISLTEDDRALLDAEAARTGRSISALIRDAVVQAYGSKRGAQDDLQAIEDAFGSWRDRDIDGGSYVEGIRSGTRLA
EARAR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References