Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1661998..1662625 Replicon chromosome
Accession NC_018867
Organism Dehalobacter sp. CF

Toxin (Protein)


Gene name pemK Uniprot ID K4L4V2
Locus tag DCF50_RS07975 Protein ID WP_015043684.1
Coordinates 1661998..1662348 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1C2Y501
Locus tag DCF50_RS07980 Protein ID WP_019225279.1
Coordinates 1662338..1662625 (-) Length 96 a.a.

Genomic Context

DCF50_RS07995DCF50_RS07955DCF50_RS07960DCF50_RS07965DCF50_RS07970DCF50_RS07975DCF50_RS07980DCF50_RS07985DCF50_RS07990DCF50_RS08000DCF50_RS08005DCF50_RS08010
Location: 1665153..1665809 (657 bp)
Type: Others
Protein ID: WP_015043688.1
Location: 1657032..1657742 (711 bp)
Type: Others
Protein ID: WP_015043680.1
Location: 1657815..1658240 (426 bp)
Type: Others
Protein ID: WP_015043681.1
Location: 1658258..1659484 (1227 bp)
Type: Others
Protein ID: WP_015043682.1
Location: 1659687..1661825 (2139 bp)
Type: Others
Protein ID: WP_015043683.1
Location: 1661998..1662348 (351 bp)
Type: Toxin
Protein ID: WP_015043684.1
Location: 1662338..1662625 (288 bp)
Type: Antitoxin
Protein ID: WP_019225279.1
Location: 1662785..1663585 (801 bp)
Type: Others
Protein ID: WP_015043686.1
Location: 1663582..1665009 (1428 bp)
Type: Others
Protein ID: WP_015043687.1
Location: 1665877..1666317 (441 bp)
Type: Others
Protein ID: WP_015043689.1
Location: 1666359..1666868 (510 bp)
Type: Others
Protein ID: WP_015043690.1
Location: 1666894..1667388 (495 bp)
Type: Others
Protein ID: WP_015043691.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DCF50_RS079551657032..1657742-711WP_015043680.1tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB-
DCF50_RS079601657815..1658240-426WP_015043681.1tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE-
DCF50_RS079651658258..1659484-1227WP_015043682.1amidohydrolase-
DCF50_RS079701659687..1661825-2139WP_015043683.1RNA-binding transcriptional accessory protein-
DCF50_RS079751661998..1662348-351WP_015043684.1type II toxin-antitoxin system PemK/MazF family toxinToxin
DCF50_RS079801662338..1662625-288WP_019225279.1hypothetical proteinAntitoxin
DCF50_RS079851662785..1663585-801WP_015043686.1glutamine amidotransferase-
DCF50_RS079901663582..1665009-1428WP_015043687.1Mur ligase family protein-
DCF50_RS079951665153..1665809+657WP_015043688.1gamma carbonic anhydrase family protein-
DCF50_RS080001665877..1666317-441WP_015043689.1MOSC domain-containing protein-
DCF50_RS080051666359..1666868-510WP_015043690.1molybdopterin-guanine dinucleotide biosynthesis protein B-
DCF50_RS080101666894..1667388-495WP_015043691.1MogA/MoaB family molybdenum cofactor biosynthesis protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-38)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12801.78 Da        Isoelectric Point: 5.2375

>T28423 WP_015043684.1 NC_018867:c1662348-1661998 [Dehalobacter sp. CF]
MSIKRGEIFYAELNPVVGSEQGGTRPVLVIQNDIGNQYSPTTIIAAITSQISKAKLPTHVEVKAKRSGLERDSVILTEQI
RTIDKSRLKEKVAVLDEEVMLRVDEAIEISLGLTEI

Download         Length: 351 bp

>T28423 NC_018867:c1662348-1661998 [Dehalobacter sp. CF]
ATGAGTATTAAACGCGGGGAGATTTTTTATGCGGAACTAAACCCCGTTGTAGGTTCTGAACAAGGCGGCACCAGGCCGGT
CTTGGTTATTCAGAATGATATTGGAAACCAGTATAGCCCGACAACAATTATCGCAGCAATTACATCCCAGATTTCAAAAG
CCAAACTGCCGACCCATGTGGAAGTCAAAGCGAAACGAAGTGGTTTGGAAAGAGATTCTGTTATTTTGACTGAACAAATC
AGAACGATCGATAAGAGCCGTTTGAAGGAAAAAGTCGCAGTGCTCGACGAGGAAGTAATGCTCAGGGTTGATGAAGCTAT
TGAAATAAGCCTTGGGCTGACGGAGATCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10996.59 Da        Isoelectric Point: 4.3854

>AT28423 WP_019225279.1 NC_018867:c1662625-1662338 [Dehalobacter sp. CF]
MAETRRIVVCLPESIIEEVDEIVSSEKLNRSDFIKEAVYSVLIERRKAGIREQMRQGYVEMAQINLSMAVDLCQAEEEAT
MRYEGKLAWSVGYEY

Download         Length: 288 bp

>AT28423 NC_018867:c1662625-1662338 [Dehalobacter sp. CF]
TTGGCAGAGACTAGGCGTATTGTTGTATGTTTGCCGGAAAGCATTATTGAGGAAGTAGACGAAATCGTATCGTCAGAGAA
GTTAAACCGGAGTGATTTTATCAAAGAAGCTGTTTACAGTGTATTGATTGAACGGCGAAAAGCAGGAATACGAGAGCAGA
TGCGGCAGGGATATGTTGAAATGGCTCAAATCAACCTGTCGATGGCAGTAGATTTATGCCAGGCTGAAGAAGAGGCAACC
ATGCGTTATGAAGGGAAACTAGCTTGGAGTGTCGGGTATGAGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBK4L4V2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1C2Y501

References