Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4099220..4100791 Replicon chromosome
Accession NZ_CP127389
Organism Proteus sp. HZ0627

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QQS39_RS18630 Protein ID WP_285805154.1
Coordinates 4099220..4100533 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QQS39_RS18635 Protein ID WP_151436533.1
Coordinates 4100534..4100791 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQS39_RS18615 (QQS39_18615) 4095302..4097383 + 2082 WP_285805152.1 TonB-dependent receptor -
QQS39_RS18620 (QQS39_18620) 4097464..4098243 + 780 WP_285805153.1 ABC transporter ATP-binding protein -
QQS39_RS18625 (QQS39_18625) 4098343..4098804 - 462 WP_151436530.1 DUF1097 domain-containing protein -
QQS39_RS18630 (QQS39_18630) 4099220..4100533 - 1314 WP_285805154.1 type II toxin-antitoxin system HipA family toxin Toxin
QQS39_RS18635 (QQS39_18635) 4100534..4100791 - 258 WP_151436533.1 helix-turn-helix domain-containing protein Antitoxin
QQS39_RS18640 (QQS39_18640) 4100940..4102304 - 1365 WP_023583363.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
QQS39_RS18645 (QQS39_18645) 4102435..4104075 - 1641 WP_151436534.1 membrane protein insertase YidC -
QQS39_RS18650 (QQS39_18650) 4104078..4104338 - 261 WP_072064717.1 membrane protein insertion efficiency factor YidD -
QQS39_RS18655 (QQS39_18655) 4104302..4104661 - 360 WP_071788569.1 ribonuclease P protein component -
QQS39_RS18660 (QQS39_18660) 4104679..4104822 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49643.57 Da        Isoelectric Point: 6.5736

>T284228 WP_285805154.1 NZ_CP127389:c4100533-4099220 [Proteus sp. HZ0627]
MASLDVYMNEYYVGIFTKKSSGAHSFQYAEEWVNQQGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVTRYN
ANSNQPFDLLTAVGADTVGALRLLPHGSTPANIKKIEYSKLNESELERILLGYQSSTPLGMLEEYTDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSNSVENEYLCTLIAKEFGLSVPHCSIIKTKNIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMSYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLQASRGKKYAIEQIFPRHFYKTAETVGFERSLLTDIFNYFYTEM
DSVIERVKQQLPKDFPTEISNTILNGMKARSTRLATI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9840.42 Da        Isoelectric Point: 10.2462

>AT284228 WP_151436533.1 NZ_CP127389:c4100791-4100534 [Proteus sp. HZ0627]
MIIINAYQLSVHLKDVRLTKKLSQGKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNSLARKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References