Detailed information of TA system TA284223

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 1642639..1643992
• Replicon: chromosome
• Accession: NZ_CP127389
• Organism: Proteus sp. HZ0627

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: QQS39_RS07630
• Protein ID: WP_285805676.1
• Coordinates: 1642639..1643604 (-)
• Length: 322 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: QQS39_RS07635
• Protein ID: WP_151434923.1
• Coordinates: 1643588..1643992 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQS39_RS07620 (QQS39_07620)	1639916..1641268	+	1353	WP_285805674.1	OprD family outer membrane porin	-
QQS39_RS07625 (QQS39_07625)	1641676..1642554	+	879	WP_285805675.1	protease HtpX	-
QQS39_RS07630 (QQS39_07630)	1642639..1643604	-	966	WP_285805676.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QQS39_RS07635 (QQS39_07635)	1643588..1643992	-	405	WP_151434923.1	DUF6088 family protein	Antitoxin
QQS39_RS07640 (QQS39_07640)	1644367..1645221	-	855	WP_285805883.1	hypothetical protein	-
QQS39_RS07645 (QQS39_07645)	1645366..1646757	-	1392	WP_151434924.1	L-cystine transporter	-
QQS39_RS07650 (QQS39_07650)	1647001..1647567	-	567	WP_151434925.1	metal-dependent hydrolase	-
QQS39_RS07655 (QQS39_07655)	1647877..1648545	-	669	WP_285805677.1	hexitol phosphatase HxpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (42-298)

Antitoxin

• Protein of unknown function DUF6088 (6-132)

Sequences

Toxin

Protein

• Length: 322 a.a.
• Molecular weight: 37706.45 Da
• Isoelectric Point: 8.0321

>T284223 WP_285805676.1 NZ_CP127389:c1643604-1642639 [Proteus sp. HZ0627]
MKKQIDLFPDVADALGIDSVSIVEKDFYIIELLKMIKDAAYHSHQLVFSGGTALSKSGIALNRMSEDVDIKMVPNVRFLS
KSREQRKKIRRELIGSIIKKIESLDFFKINLENAIKRDEYRYYEVEIQYPQKHQQAPCLRPFIKLEFIETELLEPPKNRN
ISSLVTQLTDQGDVIESLPCATNESTHVEKLISIMRRTASLNRGYDRFDDKSLVRHIYDNYCIVTHQPPDYQKLSIFMYN
CIQQDIARYSNQYPEFCEFPLKELQLGLDRLRDDPIHEQRYLKFVLPMVFSKNKITWKNAYATFHTTASILLNILNEKYY
N

Nucleotide

• Length: 966 bp

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15069.51 Da
• Isoelectric Point: 10.9154

>AT284223 WP_151434923.1 NZ_CP127389:c1643992-1643588 [Proteus sp. HZ0627]
MTIKDKIETRLKRSKRNVFFRKDFNDIAGYDQIGRVLNLLIQEGVLLRVGQGVYTKARRNQITGKTMPAAPGGSASVIIE
TLDRLKIPYLLGDATKAYNEGSSTQIPAYVEIKTPRRFSRKLIIGNSKINEKTN

Nucleotide

• Length: 405 bp