Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-MazE
Location 843305..843894 Replicon chromosome
Accession NZ_CP127382
Organism Aerococcus urinae strain UMB3669

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag DBT50_RS06690 Protein ID WP_111852369.1
Coordinates 843541..843894 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag DBT50_RS06685 Protein ID WP_111852368.1
Coordinates 843305..843547 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBT50_RS06655 (DBT50_006655) 838429..838935 + 507 WP_111852361.1 hypothetical protein -
DBT50_RS06660 (DBT50_006660) 839068..840204 + 1137 WP_111852362.1 hypothetical protein -
DBT50_RS06665 (DBT50_006665) 840356..840790 + 435 WP_111852363.1 GNAT family N-acetyltransferase -
DBT50_RS06670 (DBT50_006670) 840924..841559 + 636 WP_111852364.1 hypothetical protein -
DBT50_RS06675 (DBT50_006675) 842017..842364 + 348 WP_111852366.1 hypothetical protein -
DBT50_RS06680 (DBT50_006680) 842485..843042 - 558 WP_111852367.1 isochorismatase family protein -
DBT50_RS06685 (DBT50_006685) 843305..843547 + 243 WP_111852368.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DBT50_RS06690 (DBT50_006690) 843541..843894 + 354 WP_111852369.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DBT50_RS06695 (DBT50_006695) 844149..844277 + 129 WP_258454722.1 hypothetical protein -
DBT50_RS06700 (DBT50_006700) 844574..845971 + 1398 WP_111852370.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
DBT50_RS06705 (DBT50_006705) 846188..846616 + 429 WP_111853437.1 MarR family transcriptional regulator -
DBT50_RS06710 (DBT50_006710) 846609..848882 + 2274 WP_111853438.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-102)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13883.83 Da        Isoelectric Point: 9.2456

>T284219 WP_111852369.1 NZ_CP127382:843541-843894 [Aerococcus urinae]
MVMRQGDIFYVNFNPSIGHEQRNSRPAIVLSHDLIFQTSHMAIVAPISTTKRNYPAYYELQETDQIKGKVLLNQSKALDL
YHRQVSRENFIERAKPNEFQRIIHRYKLLFDLVDDYQ

Download         Length: 354 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9227.51 Da        Isoelectric Point: 4.3228

>AT284219 WP_111852368.1 NZ_CP127382:843305-843547 [Aerococcus urinae]
MQTKIAQWGNSKAIRIPSTIVKQLNLKDNQVLSLEIKDQALVIKPKEAETIQELFADYKTSFTYEEEMDWGPAVGEEIEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References