Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-MazE
Location 843305..843894 Replicon chromosome
Accession NZ_CP127382
Organism Aerococcus urinae strain UMB3669

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag DBT50_RS06690 Protein ID WP_111852369.1
Coordinates 843541..843894 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag DBT50_RS06685 Protein ID WP_111852368.1
Coordinates 843305..843547 (+) Length 81 a.a.

Genomic Context

DBT50_RS06655DBT50_RS06660DBT50_RS06665DBT50_RS06670DBT50_RS06675DBT50_RS06685DBT50_RS06690DBT50_RS06695DBT50_RS06700DBT50_RS06705DBT50_RS06710DBT50_RS06680
Location: 838429..838935 (507 bp)
Type: Others
Protein ID: WP_111852361.1
Location: 839068..840204 (1137 bp)
Type: Others
Protein ID: WP_111852362.1
Location: 840356..840790 (435 bp)
Type: Others
Protein ID: WP_111852363.1
Location: 840924..841559 (636 bp)
Type: Others
Protein ID: WP_111852364.1
Location: 842017..842364 (348 bp)
Type: Others
Protein ID: WP_111852366.1
Location: 843305..843547 (243 bp)
Type: Antitoxin
Protein ID: WP_111852368.1
Location: 843541..843894 (354 bp)
Type: Toxin
Protein ID: WP_111852369.1
Location: 844149..844277 (129 bp)
Type: Others
Protein ID: WP_258454722.1
Location: 844574..845971 (1398 bp)
Type: Others
Protein ID: WP_111852370.1
Location: 846188..846616 (429 bp)
Type: Others
Protein ID: WP_111853437.1
Location: 846609..848882 (2274 bp)
Type: Others
Protein ID: WP_111853438.1
Location: 842485..843042 (558 bp)
Type: Others
Protein ID: WP_111852367.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DBT50_RS06655 (DBT50_006655)838429..838935+507WP_111852361.1hypothetical protein-
DBT50_RS06660 (DBT50_006660)839068..840204+1137WP_111852362.1hypothetical protein-
DBT50_RS06665 (DBT50_006665)840356..840790+435WP_111852363.1GNAT family N-acetyltransferase-
DBT50_RS06670 (DBT50_006670)840924..841559+636WP_111852364.1hypothetical protein-
DBT50_RS06675 (DBT50_006675)842017..842364+348WP_111852366.1hypothetical protein-
DBT50_RS06680 (DBT50_006680)842485..843042-558WP_111852367.1isochorismatase family protein-
DBT50_RS06685 (DBT50_006685)843305..843547+243WP_111852368.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
DBT50_RS06690 (DBT50_006690)843541..843894+354WP_111852369.1type II toxin-antitoxin system PemK/MazF family toxinToxin
DBT50_RS06695 (DBT50_006695)844149..844277+129WP_258454722.1hypothetical protein-
DBT50_RS06700 (DBT50_006700)844574..845971+1398WP_111852370.123S rRNA (uracil(1939)-C(5))-methyltransferase RlmD-
DBT50_RS06705 (DBT50_006705)846188..846616+429WP_111853437.1MarR family transcriptional regulator-
DBT50_RS06710 (DBT50_006710)846609..848882+2274WP_111853438.1ATP-binding cassette domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-102)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13883.83 Da        Isoelectric Point: 9.2456

>T284219 WP_111852369.1 NZ_CP127382:843541-843894 [Aerococcus urinae]
MVMRQGDIFYVNFNPSIGHEQRNSRPAIVLSHDLIFQTSHMAIVAPISTTKRNYPAYYELQETDQIKGKVLLNQSKALDL
YHRQVSRENFIERAKPNEFQRIIHRYKLLFDLVDDYQ

Download         Length: 354 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9227.51 Da        Isoelectric Point: 4.3228

>AT284219 WP_111852368.1 NZ_CP127382:843305-843547 [Aerococcus urinae]
MQTKIAQWGNSKAIRIPSTIVKQLNLKDNQVLSLEIKDQALVIKPKEAETIQELFADYKTSFTYEEEMDWGPAVGEEIEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References