Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 455070..455641 Replicon chromosome
Accession NZ_CP127382
Organism Aerococcus urinae strain UMB3669

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DBT50_RS04935 Protein ID WP_111853118.1
Coordinates 455309..455641 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DBT50_RS04930 Protein ID WP_111853119.1
Coordinates 455070..455315 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBT50_RS04915 (DBT50_004915) 451561..453096 - 1536 WP_111853121.1 RNA-directed DNA polymerase -
DBT50_RS04920 (DBT50_004920) 453250..453384 - 135 WP_258455373.1 hypothetical protein -
DBT50_RS04925 (DBT50_004925) 454042..454398 - 357 WP_146742898.1 hypothetical protein -
DBT50_RS04930 (DBT50_004930) 455070..455315 + 246 WP_111853119.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DBT50_RS04935 (DBT50_004935) 455309..455641 + 333 WP_111853118.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DBT50_RS04940 (DBT50_004940) 455765..455929 - 165 WP_216403123.1 hypothetical protein -
DBT50_RS04945 (DBT50_004945) 456406..457794 - 1389 WP_111853117.1 oligosaccharide flippase family protein -
DBT50_RS04950 (DBT50_004950) 458547..458831 - 285 WP_285936136.1 acyltransferase family protein -
DBT50_RS04955 (DBT50_004955) 458853..459854 - 1002 WP_285936137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 451561..467771 16210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12768.89 Da        Isoelectric Point: 9.2415

>T284218 WP_111853118.1 NZ_CP127382:455309-455641 [Aerococcus urinae]
MVKVKQGSIIKINLDPKQGHEQKGYRPYICLSHGIVTKYSNIAIFAPISNTKRKYPFYVELEHTKTTGKVLLDQLLTIDF
NARDYNYIEQVPEDILIDLLARVKVLFEKE

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9375.79 Da        Isoelectric Point: 7.0109

>AT284218 WP_111853119.1 NZ_CP127382:455070-455315 [Aerococcus urinae]
MPLTINKWGNSSAIRLPKQLLEELNLSQGDKLDYQVKNGQLIIKKITEVPELTIKDLFENYHGNPVNEKPVLFEQKGNEK
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References