Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 455070..455641 Replicon chromosome
Accession NZ_CP127382
Organism Aerococcus urinae strain UMB3669

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DBT50_RS04935 Protein ID WP_111853118.1
Coordinates 455309..455641 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DBT50_RS04930 Protein ID WP_111853119.1
Coordinates 455070..455315 (+) Length 82 a.a.

Genomic Context

DBT50_RS04930DBT50_RS04935DBT50_RS04915DBT50_RS04920DBT50_RS04925DBT50_RS04940DBT50_RS04945DBT50_RS04950DBT50_RS04955
Location: 455070..455315 (246 bp)
Type: Antitoxin
Protein ID: WP_111853119.1
Location: 455309..455641 (333 bp)
Type: Toxin
Protein ID: WP_111853118.1
Location: 451561..453096 (1536 bp)
Type: Others
Protein ID: WP_111853121.1
Location: 453250..453384 (135 bp)
Type: Others
Protein ID: WP_258455373.1
Location: 454042..454398 (357 bp)
Type: Others
Protein ID: WP_146742898.1
Location: 455765..455929 (165 bp)
Type: Others
Protein ID: WP_216403123.1
Location: 456406..457794 (1389 bp)
Type: Others
Protein ID: WP_111853117.1
Location: 458547..458831 (285 bp)
Type: Others
Protein ID: WP_285936136.1
Location: 458853..459854 (1002 bp)
Type: Others
Protein ID: WP_285936137.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DBT50_RS04915 (DBT50_004915)451561..453096-1536WP_111853121.1RNA-directed DNA polymerase-
DBT50_RS04920 (DBT50_004920)453250..453384-135WP_258455373.1hypothetical protein-
DBT50_RS04925 (DBT50_004925)454042..454398-357WP_146742898.1hypothetical protein-
DBT50_RS04930 (DBT50_004930)455070..455315+246WP_111853119.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
DBT50_RS04935 (DBT50_004935)455309..455641+333WP_111853118.1type II toxin-antitoxin system PemK/MazF family toxinToxin
DBT50_RS04940 (DBT50_004940)455765..455929-165WP_216403123.1hypothetical protein-
DBT50_RS04945 (DBT50_004945)456406..457794-1389WP_111853117.1oligosaccharide flippase family protein-
DBT50_RS04950 (DBT50_004950)458547..458831-285WP_285936136.1acyltransferase family protein-
DBT50_RS04955 (DBT50_004955)458853..459854-1002WP_285936137.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--451561..46777116210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12768.89 Da        Isoelectric Point: 9.2415

>T284218 WP_111853118.1 NZ_CP127382:455309-455641 [Aerococcus urinae]
MVKVKQGSIIKINLDPKQGHEQKGYRPYICLSHGIVTKYSNIAIFAPISNTKRKYPFYVELEHTKTTGKVLLDQLLTIDF
NARDYNYIEQVPEDILIDLLARVKVLFEKE

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9375.79 Da        Isoelectric Point: 7.0109

>AT284218 WP_111853119.1 NZ_CP127382:455070-455315 [Aerococcus urinae]
MPLTINKWGNSSAIRLPKQLLEELNLSQGDKLDYQVKNGQLIIKKITEVPELTIKDLFENYHGNPVNEKPVLFEQKGNEK
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References