Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2069222..2069892 Replicon chromosome
Accession NZ_CP127378
Organism Xanthomonas fragariae strain LMG 703

Toxin (Protein)


Gene name vapC Uniprot ID A0A1Y6H9H7
Locus tag OW158_RS09680 Protein ID WP_002805728.1
Coordinates 2069473..2069892 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1Y6HLT7
Locus tag OW158_RS09675 Protein ID WP_002805732.1
Coordinates 2069222..2069476 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW158_RS09650 (OW158_09650) 2064807..2065802 - 996 WP_231892738.1 LuxR family transcriptional regulator -
OW158_RS09655 (OW158_09655) 2065893..2066126 + 234 WP_002805742.1 hypothetical protein -
OW158_RS09660 (OW158_09660) 2066130..2067008 + 879 WP_002805739.1 helicase RepA family protein -
OW158_RS09665 (OW158_09665) 2066980..2067867 + 888 WP_172404498.1 replication protein C, IncQ-type -
OW158_RS09670 (OW158_09670) 2068529..2068810 + 282 WP_002805735.1 TraK family protein -
OW158_RS09675 (OW158_09675) 2069222..2069476 + 255 WP_002805732.1 Arc family DNA-binding protein Antitoxin
OW158_RS09680 (OW158_09680) 2069473..2069892 + 420 WP_002805728.1 type II toxin-antitoxin system VapC family toxin Toxin
OW158_RS09685 (OW158_09685) 2070049..2070660 + 612 Protein_1853 P-type conjugative transfer protein TrbJ -
OW158_RS09690 (OW158_09690) 2070749..2070991 + 243 Protein_1854 transposase -
OW158_RS09695 (OW158_09695) 2071109..2072475 + 1367 Protein_1855 IS5 family transposase -
OW158_RS09700 (OW158_09700) 2072498..2073403 + 906 Protein_1856 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2036507..2072379 35872
- flank IS/Tn - - 2063396..2064733 1337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14879.07 Da        Isoelectric Point: 5.1890

>T284212 WP_002805728.1 NZ_CP127378:2069473-2069892 [Xanthomonas fragariae]
MIVLDTNVVSEAIKPEPNPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9522.89 Da        Isoelectric Point: 5.7425

>AT284212 WP_002805732.1 NZ_CP127378:2069222-2069476 [Xanthomonas fragariae]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRQVVLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6H9H7

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y6HLT7

References