Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 242856..243498 Replicon chromosome
Accession NZ_CP127376
Organism Bacillus arachidis strain YX15

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag QRY57_RS03000 Protein ID WP_000635965.1
Coordinates 243148..243498 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8PTJ6
Locus tag QRY57_RS02995 Protein ID WP_000004571.1
Coordinates 242856..243143 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRY57_RS02970 (QRY57_02975) 238718..239680 + 963 WP_026592770.1 UV DNA damage repair endonuclease UvsE -
QRY57_RS02975 (QRY57_02980) 239684..240244 - 561 WP_081811071.1 rhomboid family intramembrane serine protease -
QRY57_RS02980 (QRY57_02985) 240337..240696 + 360 WP_026592771.1 holo-ACP synthase -
QRY57_RS02985 (QRY57_02990) 240853..241800 + 948 WP_141527996.1 outer membrane lipoprotein carrier protein LolA -
QRY57_RS02990 (QRY57_02995) 241920..242540 + 621 Protein_229 alanine racemase -
QRY57_RS02995 (QRY57_03000) 242856..243143 + 288 WP_000004571.1 antitoxin EndoAI Antitoxin
QRY57_RS03000 (QRY57_03005) 243148..243498 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QRY57_RS03005 (QRY57_03010) 243564..245732 + 2169 WP_286016632.1 Tex family protein -
QRY57_RS03010 (QRY57_03015) 245836..245952 - 117 WP_090694145.1 cortex morphogenetic protein CmpA -
QRY57_RS03015 (QRY57_03020) 246208..246693 + 486 WP_286016633.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T284210 WP_000635965.1 NZ_CP127376:243148-243498 [Bacillus arachidis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10748.30 Da        Isoelectric Point: 8.9605

>AT284210 WP_000004571.1 NZ_CP127376:242856-243143 [Bacillus arachidis]
VSESSVTTEIVVRLPKQVVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB R8PTJ6

References