Detailed information of TA system TA028421

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3562878..3563513
• Replicon: chromosome
• Accession: NC_018829
• Organism: Bordetella bronchiseptica MO149

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7VZH0
• Locus tag: BN115_RS16575
• Protein ID: WP_010930090.1
• Coordinates: 3562878..3563060 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BN115_RS16580
• Protein ID: WP_015041744.1
• Coordinates: 3563121..3563513 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN115_RS16555	3558597..3559178	+	582	WP_003813377.1	OmpA family protein	-
BN115_RS16560	3559304..3560029	+	726	WP_033448326.1	bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG	-
BN115_RS16565	3560026..3560703	+	678	WP_015041742.1	HAD-IA family hydrolase	-
BN115_RS16570	3560920..3562104	+	1185	WP_015041743.1	MFS transporter	-
BN115_RS16575	3562878..3563060	+	183	WP_010930090.1	type II toxin-antitoxin system HicA family toxin	Toxin
BN115_RS16580	3563121..3563513	+	393	WP_015041744.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BN115_RS16585	3563790..3564701	-	912	WP_003821497.1	LysR family transcriptional regulator	-
BN115_RS16590	3564826..3565800	+	975	WP_004566318.1	tripartite tricarboxylate transporter substrate binding protein	-
BN115_RS16595	3565835..3566194	+	360	WP_003821494.1	hypothetical protein	-
BN115_RS16600	3566261..3567433	+	1173	WP_003821493.1	thiolase domain-containing protein	-
BN115_RS16605	3567437..3567859	+	423	WP_004566320.1	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6602.72 Da
• Isoelectric Point: 10.9062

>T28421 WP_010930090.1 NC_018829:3562878-3563060 [Bordetella bronchiseptica MO149]
MDSKELIKQLERSGWTLRGVKGSHHVFTHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T28421 NC_018829:3562878-3563060 [Bordetella bronchiseptica MO149]
ATGGACAGCAAAGAACTGATCAAGCAGCTTGAGCGGTCCGGGTGGACACTGCGGGGCGTTAAGGGATCCCACCACGTTTT
CACCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACCCAAAAAAGGATCTCGGCATCGGACTACTAAACAGCATCC
TCAAAGCAGCTGGTTTGAAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14031.79 Da
• Isoelectric Point: 4.2876

>AT28421 WP_015041744.1 NC_018829:3563121-3563513 [Bordetella bronchiseptica MO149]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAAIPPATSIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT28421 NC_018829:3563121-3563513 [Bordetella bronchiseptica MO149]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGGGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCAGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCGCCATTCCTCCGGCAACCAGCATCGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACCGTTGAGCGCGTGAACATCACGATCCCGCGCCGCATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7VZH0