Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 4738978..4739611 Replicon chromosome
Accession NZ_CP127363
Organism Paracidovorax citrulli strain KACC 17005

Toxin (Protein)


Gene name vapC Uniprot ID A1TJP6
Locus tag QRO08_RS22015 Protein ID WP_011793755.1
Coordinates 4738978..4739391 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B0DRJ9
Locus tag QRO08_RS22020 Protein ID WP_041827216.1
Coordinates 4739378..4739611 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRO08_RS21990 (QRO08_21990) 4733985..4735022 - 1038 WP_011793760.1 anthranilate phosphoribosyltransferase -
QRO08_RS21995 (QRO08_21995) 4735055..4735738 - 684 WP_011793759.1 LysE family translocator -
QRO08_RS22000 (QRO08_22000) 4735810..4736382 - 573 WP_011793758.1 aminodeoxychorismate/anthranilate synthase component II -
QRO08_RS22005 (QRO08_22005) 4737067..4738581 + 1515 WP_011793757.1 conjugal transfer protein TraG N-terminal domain-containing protein -
QRO08_RS22010 (QRO08_22010) 4738595..4738957 - 363 WP_011793756.1 DUF3742 family protein -
QRO08_RS22015 (QRO08_22015) 4738978..4739391 - 414 WP_011793755.1 PIN domain-containing protein Toxin
QRO08_RS22020 (QRO08_22020) 4739378..4739611 - 234 WP_041827216.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4695011..4864210 169199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15147.48 Da        Isoelectric Point: 6.2136

>T284208 WP_011793755.1 NZ_CP127363:c4739391-4738978 [Paracidovorax citrulli]
MAAGKGKVFLDSNVVLYLLSEDAAKADSAEALLHRRPVISVQVLNEVTHVCVRKLKMGWGEVGQFLALVREFCSIVPLTV
EVHDRARQLAERHQLSFYDACIVAAAAAEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8518.76 Da        Isoelectric Point: 8.7857

>AT284208 WP_041827216.1 NZ_CP127363:c4739611-4739378 [Paracidovorax citrulli]
MLVAKWGNSLAVRLPANVVEALELREGDDIEIFVGDARSFAVSKKPGAEAMLERLRTFRGKLPADFKFNRDEANGRG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1TJP6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0DRJ9

References