Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 613951..614584 Replicon chromosome
Accession NZ_CP127362
Organism Paracidovorax citrulli strain KACC 17913

Toxin (Protein)


Gene name vapC Uniprot ID A1TJP6
Locus tag QRO12_RS02895 Protein ID WP_011793755.1
Coordinates 614171..614584 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B0DRJ9
Locus tag QRO12_RS02890 Protein ID WP_041827216.1
Coordinates 613951..614184 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRO12_RS02890 (QRO12_02890) 613951..614184 + 234 WP_041827216.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QRO12_RS02895 (QRO12_02895) 614171..614584 + 414 WP_011793755.1 PIN domain-containing protein Toxin
QRO12_RS02900 (QRO12_02900) 614605..614967 + 363 WP_011793756.1 DUF3742 family protein -
QRO12_RS02905 (QRO12_02905) 614981..616495 - 1515 WP_011793757.1 conjugal transfer protein TraG N-terminal domain-containing protein -
QRO12_RS02910 (QRO12_02910) 617180..617752 + 573 WP_011793758.1 aminodeoxychorismate/anthranilate synthase component II -
QRO12_RS02915 (QRO12_02915) 617824..618507 + 684 WP_011793759.1 LysE family translocator -
QRO12_RS02920 (QRO12_02920) 618540..619577 + 1038 WP_011793760.1 anthranilate phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 400396..656368 255972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15147.48 Da        Isoelectric Point: 6.2136

>T284205 WP_011793755.1 NZ_CP127362:614171-614584 [Paracidovorax citrulli]
MAAGKGKVFLDSNVVLYLLSEDAAKADSAEALLHRRPVISVQVLNEVTHVCVRKLKMGWGEVGQFLALVREFCSIVPLTV
EVHDRARQLAERHQLSFYDACIVAAAAAEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8518.76 Da        Isoelectric Point: 8.7857

>AT284205 WP_041827216.1 NZ_CP127362:613951-614184 [Paracidovorax citrulli]
MLVAKWGNSLAVRLPANVVEALELREGDDIEIFVGDARSFAVSKKPGAEAMLERLRTFRGKLPADFKFNRDEANGRG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1TJP6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0DRJ9

References