Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 13679..14220 Replicon plasmid pCh101
Accession NZ_CP127318
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QRM71_RS26760 Protein ID WP_285978951.1
Coordinates 13679..13951 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag QRM71_RS26765 Protein ID WP_285978946.1
Coordinates 13951..14220 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS26740 (QRM71_26740) 10002..10409 - 408 WP_285978944.1 VapA/VapB family virulence-associated protein -
QRM71_RS26745 (QRM71_26745) 10977..11366 - 390 Protein_14 transposase -
QRM71_RS26750 (QRM71_26750) 11942..12236 + 295 Protein_15 transposase -
QRM71_RS26755 (QRM71_26755) 12320..13369 - 1050 WP_285978945.1 hypothetical protein -
QRM71_RS26760 (QRM71_26760) 13679..13951 - 273 WP_285978951.1 type II toxin-antitoxin system toxin YacB Toxin
QRM71_RS26765 (QRM71_26765) 13951..14220 - 270 WP_285978946.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QRM71_RS26770 (QRM71_26770) 14616..15626 + 1011 WP_000487119.1 IS110 family transposase -
QRM71_RS26775 (QRM71_26775) 16204..16794 + 591 WP_000086535.1 recombinase family protein -
QRM71_RS26780 (QRM71_26780) 16841..16999 + 159 Protein_21 integrase core domain-containing protein -
QRM71_RS26785 (QRM71_26785) 17149..18146 + 998 Protein_22 ABC transporter substrate-binding protein -
QRM71_RS26790 (QRM71_26790) 18146..19183 + 1038 WP_000110580.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - cnf / cnf1 / cnf1 / vat / vat 1..156007 156007
- inside IScluster/Tn - - 16204..35861 19657


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10509.07 Da        Isoelectric Point: 8.4615

>T284197 WP_285978951.1 NZ_CP127318:c13951-13679 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTTQK

Download         Length: 273 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10203.46 Da        Isoelectric Point: 6.4681

>AT284197 WP_285978946.1 NZ_CP127318:c14220-13951 [Escherichia coli]
MTQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLSHDMVESSATAWRD
EMSGKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References