Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 5315831..5316536 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag QRM71_RS25870 Protein ID WP_000539521.1
Coordinates 5316150..5316536 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QRM71_RS25865 Protein ID WP_001280945.1
Coordinates 5315831..5316160 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS25850 (5310989) 5310989..5311900 + 912 WP_001236018.1 glutathione ABC transporter permease GsiD -
QRM71_RS25855 (5312078) 5312078..5314425 + 2348 Protein_5048 EAL domain-containing protein -
QRM71_RS25860 (5314433) 5314433..5315761 + 1329 WP_032352848.1 GGDEF domain-containing protein -
QRM71_RS25865 (5315831) 5315831..5316160 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
QRM71_RS25870 (5316150) 5316150..5316536 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRM71_RS25875 (5316762) 5316762..5318087 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QRM71_RS25880 (5318300) 5318300..5318683 + 384 WP_000497137.1 biofilm formation regulator BssR -
QRM71_RS25885 (5318794) 5318794..5319909 + 1116 WP_000555050.1 aldose sugar dehydrogenase YliI -
QRM71_RS25890 (5319906) 5319906..5320532 - 627 WP_032352846.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T284189 WP_000539521.1 NZ_CP127316:c5316536-5316150 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT284189 WP_001280945.1 NZ_CP127316:c5316160-5315831 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References