Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4811239..4811857 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QRM71_RS23410 Protein ID WP_001291435.1
Coordinates 4811239..4811457 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QRM71_RS23415 Protein ID WP_000344800.1
Coordinates 4811483..4811857 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS23375 (4806528) 4806528..4807100 + 573 WP_000779831.1 YbaY family lipoprotein -
QRM71_RS23380 (4807131) 4807131..4807442 - 312 WP_000409911.1 MGMT family protein -
QRM71_RS23390 (4807821) 4807821..4808174 + 354 WP_001550741.1 DUF1428 family protein -
QRM71_RS23395 (4808216) 4808216..4809766 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QRM71_RS23400 (4809930) 4809930..4810400 - 471 WP_000136192.1 YlaC family protein -
QRM71_RS23405 (4810516) 4810516..4811067 - 552 WP_000102564.1 maltose O-acetyltransferase -
QRM71_RS23410 (4811239) 4811239..4811457 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QRM71_RS23415 (4811483) 4811483..4811857 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QRM71_RS23420 (4812403) 4812403..4815552 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QRM71_RS23425 (4815575) 4815575..4816768 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T284188 WP_001291435.1 NZ_CP127316:c4811457-4811239 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT284188 WP_000344800.1 NZ_CP127316:c4811857-4811483 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References