Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4606028..4607717 | Replicon | chromosome |
| Accession | NZ_CP127316 | ||
| Organism | Escherichia coli strain Ch1 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | V0Z9M0 |
| Locus tag | QRM71_RS22460 | Protein ID | WP_000365809.1 |
| Coordinates | 4606797..4607717 (+) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | QRM71_RS22455 | Protein ID | WP_001550661.1 |
| Coordinates | 4606028..4606810 (+) | Length | 261 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QRM71_RS22435 (4601337) | 4601337..4601495 | - | 159 | Protein_4380 | integrase | - |
| QRM71_RS22440 (4601587) | 4601587..4601689 | - | 103 | Protein_4381 | helix-turn-helix domain-containing protein | - |
| QRM71_RS22445 (4601686) | 4601686..4602156 | - | 471 | WP_000201185.1 | hypothetical protein | - |
| QRM71_RS22450 (4602503) | 4602503..4605712 | - | 3210 | WP_285978821.1 | RNA-directed DNA polymerase | - |
| QRM71_RS22455 (4606028) | 4606028..4606810 | + | 783 | WP_001550661.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| QRM71_RS22460 (4606797) | 4606797..4607717 | + | 921 | WP_000365809.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| QRM71_RS22465 (4608151) | 4608151..4609035 | - | 885 | WP_001119037.1 | LysR family transcriptional regulator | - |
| QRM71_RS22470 (4609300) | 4609300..4610357 | + | 1058 | Protein_4387 | alpha/beta hydrolase | - |
| QRM71_RS22475 (4610499) | 4610499..4611626 | + | 1128 | WP_001550663.1 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC | 4591695..4648348 | 56653 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 34571.01 Da Isoelectric Point: 7.2649
>T284187 WP_000365809.1 NZ_CP127316:4606797-4607717 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA
Download Length: 921 bp
Antitoxin
Download Length: 261 a.a. Molecular weight: 29191.43 Da Isoelectric Point: 8.9059
>AT284187 WP_001550661.1 NZ_CP127316:4606028-4606810 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA
Download Length: 783 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|