Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4081212..4081734 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag QRM71_RS19945 Protein ID WP_001105433.1
Coordinates 4081444..4081734 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WJ36
Locus tag QRM71_RS19940 Protein ID WP_000212718.1
Coordinates 4081212..4081454 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS19920 (4077125) 4077125..4078498 + 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
QRM71_RS19925 (4078581) 4078581..4079132 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
QRM71_RS19930 (4079226) 4079226..4080578 + 1353 WP_001162176.1 metalloprotease PmbA -
QRM71_RS19935 (4080634) 4080634..4081020 + 387 WP_001232253.1 cytochrome b562 -
QRM71_RS19940 (4081212) 4081212..4081454 + 243 WP_000212718.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QRM71_RS19945 (4081444) 4081444..4081734 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRM71_RS19950 (4081735) 4081735..4082199 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QRM71_RS19955 (4082379) 4082379..4084517 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
QRM71_RS19960 (4084911) 4084911..4086566 - 1656 WP_032353022.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-66)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T284184 WP_001105433.1 NZ_CP127316:4081444-4081734 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9174.63 Da        Isoelectric Point: 5.1369

>AT284184 WP_000212718.1 NZ_CP127316:4081212-4081454 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLAYPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WJ36

References