Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4069796..4070391 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag QRM71_RS19885 Protein ID WP_000239581.1
Coordinates 4070041..4070391 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag QRM71_RS19880 Protein ID WP_001223213.1
Coordinates 4069796..4070047 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS19870 (4065461) 4065461..4069240 + 3780 WP_032352905.1 autotransporter assembly complex protein TamB -
QRM71_RS19875 (4069243) 4069243..4069584 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QRM71_RS19880 (4069796) 4069796..4070047 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QRM71_RS19885 (4070041) 4070041..4070391 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
QRM71_RS19890 (4070470) 4070470..4071000 - 531 WP_000055075.1 inorganic diphosphatase -
QRM71_RS19895 (4071310) 4071310..4072266 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QRM71_RS19900 (4072398) 4072398..4073900 + 1503 WP_279957041.1 sugar ABC transporter ATP-binding protein -
QRM71_RS19905 (4073914) 4073914..4074936 + 1023 WP_032352902.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T284183 WP_000239581.1 NZ_CP127316:4070041-4070391 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT284183 WP_001223213.1 NZ_CP127316:4069796-4070047 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References