Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3912532..3913029 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QRM71_RS19105 Protein ID WP_001173343.1
Coordinates 3912856..3913029 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QRM71_RS19100 Protein ID WP_000398619.1
Coordinates 3912532..3912828 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS19080 (3909262) 3909262..3909981 - 720 WP_000611288.1 two-component system response regulator DcuR -
QRM71_RS19085 (3909978) 3909978..3911609 - 1632 WP_032352794.1 sensor histidine kinase -
QRM71_RS19090 (3911789) 3911789..3912019 + 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
QRM71_RS19095 (3912031) 3912031..3912303 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QRM71_RS19100 (3912532) 3912532..3912828 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QRM71_RS19105 (3912856) 3912856..3913029 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QRM71_RS19110 (3913148) 3913148..3914665 - 1518 WP_000003806.1 lysine--tRNA ligase -
QRM71_RS19115 (3914902) 3914902..3916359 - 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T284181 WP_001173343.1 NZ_CP127316:3912856-3913029 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT284181 WP_000398619.1 NZ_CP127316:3912532-3912828 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References