Detailed information of TA system TA028418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2871411..2872072
• Replicon: chromosome
• Accession: NC_018829
• Organism: Bordetella bronchiseptica MO149

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C6NZK6
• Locus tag: BN115_RS13395
• Protein ID: WP_003817075.1
• Coordinates: 2871647..2872072 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BN115_RS13390
• Protein ID: WP_003812071.1
• Coordinates: 2871411..2871650 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN115_RS13355	2866446..2867249	-	804	WP_003817085.1	bacteriocin family protein	-
BN115_RS13360	2867246..2868292	-	1047	WP_003817082.1	Dyp-type peroxidase	-
BN115_RS13365	2868370..2868930	-	561	WP_015041572.1	DUF488 domain-containing protein	-
BN115_RS13370	2868927..2869160	-	234	WP_033448627.1	DUF2945 domain-containing protein	-
BN115_RS13375	2869241..2869753	-	513	WP_015041573.1	redoxin domain-containing protein	-
BN115_RS13380	2869812..2870357	-	546	WP_004567230.1	peroxidase-related enzyme	-
BN115_RS13385	2870495..2871337	+	843	WP_015041574.1	AraC family transcriptional regulator	-
BN115_RS13390	2871411..2871650	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
BN115_RS13395	2871647..2872072	+	426	WP_003817075.1	PIN domain-containing protein	Toxin
BN115_RS13400	2872182..2872646	+	465	WP_003812075.1	MarR family transcriptional regulator	-
BN115_RS13405	2872751..2874256	-	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
BN115_RS13410	2874764..2875276	+	513	WP_015041575.1	hypothetical protein	-
BN115_RS13415	2875296..2876273	-	978	WP_015041576.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14813.19 Da
• Isoelectric Point: 6.3704

>T28418 WP_003817075.1 NC_018829:2871647-2872072 [Bordetella bronchiseptica MO149]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDA
AAADAYAAVMMRAAAAGHALCATDGCIAAIATAHGLAIATRHPARFEAAGLTAVDPWHAAA

Nucleotide

• Length: 426 bp

>T28418 NC_018829:2871647-2872072 [Bordetella bronchiseptica MO149]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGCCTGGCCCGTCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCGACCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGGCTGGCCATCGCCACGCGCCACCCGGCCAGGTTCGAGGCGGCCGGGCTCACCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT28418 WP_003812071.1 NC_018829:2871411-2871650 [Bordetella bronchiseptica MO149]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT28418 NC_018829:2871411-2871650 [Bordetella bronchiseptica MO149]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACACATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAACTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C6NZK6