Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2391320..2391974 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QRM71_RS11870 Protein ID WP_000244781.1
Coordinates 2391320..2391727 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QRM71_RS11875 Protein ID WP_000354046.1
Coordinates 2391708..2391974 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS11850 (2387277) 2387277..2389010 - 1734 WP_000813226.1 single-stranded-DNA-specific exonuclease RecJ -
QRM71_RS11855 (2389016) 2389016..2389726 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRM71_RS11860 (2389751) 2389751..2390647 - 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
QRM71_RS11865 (2390759) 2390759..2391280 + 522 WP_001055865.1 flavodoxin FldB -
QRM71_RS11870 (2391320) 2391320..2391727 - 408 WP_000244781.1 protein YgfX Toxin
QRM71_RS11875 (2391708) 2391708..2391974 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QRM71_RS11880 (2392217) 2392217..2393197 + 981 WP_001562036.1 tRNA-modifying protein YgfZ -
QRM71_RS11885 (2393274) 2393274..2393933 - 660 WP_000250269.1 hemolysin III family protein -
QRM71_RS11890 (2394097) 2394097..2394408 - 312 WP_001182951.1 N(4)-acetylcytidine aminohydrolase -
QRM71_RS11895 (2394453) 2394453..2395886 + 1434 WP_001559758.1 6-phospho-beta-glucosidase BglA -
QRM71_RS11900 (2395948) 2395948..2396691 - 744 WP_032353540.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T284177 WP_000244781.1 NZ_CP127316:c2391727-2391320 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT284177 WP_000354046.1 NZ_CP127316:c2391974-2391708 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References