Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1543220..1543814 Replicon chromosome
Accession NC_018829
Organism Bordetella bronchiseptica MO149

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BN115_RS23870 Protein ID WP_003819882.1
Coordinates 1543632..1543814 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BN115_RS07205 Protein ID WP_003819880.1
Coordinates 1543220..1543609 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN115_RS07180 1539062..1540102 + 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -
BN115_RS07185 1540237..1541253 + 1017 WP_003809636.1 phosphate ABC transporter permease subunit PstC -
BN115_RS07190 1541275..1542132 + 858 WP_003809638.1 phosphate ABC transporter permease PstA -
BN115_RS07195 1542177..1542953 + 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
BN115_RS07205 1543220..1543609 - 390 WP_003819880.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BN115_RS23870 1543632..1543814 - 183 WP_003819882.1 type II toxin-antitoxin system HicA family toxin Toxin
BN115_RS07210 1544222..1544920 + 699 WP_015041235.1 gluconate 2-dehydrogenase subunit 3 family protein -
BN115_RS07215 1544924..1546693 + 1770 WP_004568200.1 GMC family oxidoreductase -
BN115_RS07220 1546704..1548059 + 1356 WP_004568199.1 cytochrome c -
BN115_RS07225 1548070..1548810 - 741 WP_004568198.1 carbonic anhydrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6822.91 Da        Isoelectric Point: 11.4375

>T28417 WP_003819882.1 NC_018829:c1543814-1543632 [Bordetella bronchiseptica MO149]
MNSADLIKRLKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKDLPTATQRSILKQAGLR

Download         Length: 183 bp

>T28417 NC_018829:c1543814-1543632 [Bordetella bronchiseptica MO149]
ATGAACAGCGCAGACCTGATCAAGCGACTGAAGGCAGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGACCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14300.00 Da        Isoelectric Point: 4.3864

>AT28417 WP_003819880.1 NC_018829:c1543609-1543220 [Bordetella bronchiseptica MO149]
MLYPIHVSKDEGSAYGAVFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYRGGYWMMVDID
LSKVSTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT28417 NC_018829:c1543609-1543220 [Bordetella bronchiseptica MO149]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGTCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCGAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAGCACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAACACGAAATGGCCGACGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References