Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 602913..603551 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0D8WF76
Locus tag QRM71_RS03090 Protein ID WP_001306887.1
Coordinates 602913..603089 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QRM71_RS03095 Protein ID WP_001270286.1
Coordinates 603135..603551 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS03070 (598535) 598535..599746 - 1212 WP_071791157.1 BenE family transporter YdcO -
QRM71_RS03075 (599799) 599799..600335 + 537 WP_000429136.1 DNA-binding transcriptional regulator SutR -
QRM71_RS03080 (600408) 600408..602369 + 1962 WP_024166512.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QRM71_RS03085 (602461) 602461..602691 - 231 WP_000494241.1 YncJ family protein -
QRM71_RS03090 (602913) 602913..603089 + 177 WP_001306887.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QRM71_RS03095 (603135) 603135..603551 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QRM71_RS03100 (603630) 603630..605036 + 1407 WP_279957258.1 PLP-dependent aminotransferase family protein -
QRM71_RS03105 (605281) 605281..606426 + 1146 WP_000047452.1 ABC transporter substrate-binding protein -
QRM71_RS03110 (606444) 606444..607457 + 1014 WP_089619990.1 ABC transporter ATP-binding protein -
QRM71_RS03115 (607458) 607458..608399 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6768.88 Da        Isoelectric Point: 11.5336

>T284167 WP_001306887.1 NZ_CP127316:602913-603089 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFRGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT284167 WP_001270286.1 NZ_CP127316:603135-603551 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8WF76

Antitoxin

Source ID Structure

References