Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 220605..221389 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag QRM71_RS01130 Protein ID WP_000613626.1
Coordinates 220605..221099 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag QRM71_RS01135 Protein ID WP_001110447.1
Coordinates 221096..221389 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS01110 (215798) 215798..216895 + 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -
QRM71_RS01115 (216895) 216895..217836 + 942 WP_001366226.1 flagellar assembly peptidoglycan hydrolase FlgJ -
QRM71_RS01120 (217902) 217902..219545 + 1644 WP_285978847.1 flagellar hook-associated protein FlgK -
QRM71_RS01125 (219557) 219557..220510 + 954 WP_001212768.1 flagellar hook-associated protein FlgL -
QRM71_RS01130 (220605) 220605..221099 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
QRM71_RS01135 (221096) 221096..221389 - 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
QRM71_RS01140 (221522) 221522..224707 - 3186 WP_285978848.1 ribonuclease E -
QRM71_RS01145 (225280) 225280..226239 + 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T284162 WP_000613626.1 NZ_CP127316:c221099-220605 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT284162 WP_001110447.1 NZ_CP127316:c221389-221096 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References