Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1053..1575 Replicon plasmid pC2501
Accession NZ_CP127315
Organism Escherichia coli strain C25

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag QRM69_RS25350 Protein ID WP_000220560.1
Coordinates 1053..1334 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag QRM69_RS25355 Protein ID WP_000121743.1
Coordinates 1324..1575 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM69_RS25335 (89) 89..304 - 216 WP_001180116.1 hypothetical protein -
QRM69_RS25340 (294) 294..539 - 246 WP_000356548.1 hypothetical protein -
QRM69_RS25345 (584) 584..907 - 324 WP_001181903.1 hypothetical protein -
QRM69_RS25350 (1053) 1053..1334 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRM69_RS25355 (1324) 1324..1575 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
QRM69_RS25360 (2798) 2798..3637 + 840 WP_001546350.1 replication initiation protein -
QRM69_RS25365 (3658) 3658..4500 + 843 WP_000435063.1 replication initiation protein -
QRM69_RS25370 (4504) 4504..4668 + 165 WP_165450845.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1C - 1..29144 29144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T284161 WP_000220560.1 NZ_CP127315:c1334-1053 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT284161 WP_000121743.1 NZ_CP127315:c1575-1324 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References