Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 5165183..5166108 | Replicon | chromosome |
| Accession | NZ_CP127314 | ||
| Organism | Escherichia coli strain C25 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | QRM69_RS25110 | Protein ID | WP_014640052.1 |
| Coordinates | 5165183..5165569 (-) | Length | 129 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | QRM69_RS25115 | Protein ID | WP_024174200.1 |
| Coordinates | 5165599..5166108 (-) | Length | 170 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QRM69_RS25070 (5160954) | 5160954..5161316 | + | 363 | WP_000135680.1 | protein YfdP | - |
| QRM69_RS25075 (5161382) | 5161382..5162206 | + | 825 | WP_021567857.1 | DUF2303 family protein | - |
| QRM69_RS25080 (5162334) | 5162334..5162870 | + | 537 | WP_021567856.1 | 5'-deoxynucleotidase | - |
| QRM69_RS25085 (5162861) | 5162861..5163223 | + | 363 | WP_001242717.1 | phage protein | - |
| QRM69_RS25090 (5163223) | 5163223..5164032 | + | 810 | WP_170896047.1 | hypothetical protein | - |
| QRM69_RS25095 (5164032) | 5164032..5164604 | + | 573 | WP_021567854.1 | 3'-5' exonuclease | - |
| QRM69_RS25100 (5164641) | 5164641..5164922 | + | 282 | WP_001093917.1 | pyocin activator PrtN family protein | - |
| QRM69_RS25105 (5164970) | 5164970..5165143 | - | 174 | WP_000390069.1 | hypothetical protein | - |
| QRM69_RS25110 (5165183) | 5165183..5165569 | - | 387 | WP_014640052.1 | hypothetical protein | Toxin |
| QRM69_RS25115 (5165599) | 5165599..5166108 | - | 510 | WP_024174200.1 | Panacea domain-containing protein | Antitoxin |
| QRM69_RS25120 (5166642) | 5166642..5167157 | + | 516 | WP_000416264.1 | zinc uptake transcriptional repressor Zur | - |
| QRM69_RS25125 (5167199) | 5167199..5167408 | - | 210 | WP_001296638.1 | CsbD family protein | - |
| QRM69_RS25130 (5167524) | 5167524..5168849 | - | 1326 | WP_001296637.1 | MATE family efflux transporter DinF | - |
| QRM69_RS25135 (5168922) | 5168922..5169530 | - | 609 | WP_000646078.1 | transcriptional repressor LexA | - |
| QRM69_RS25140 (5169640) | 5169640..5170008 | - | 369 | WP_000002907.1 | diacylglycerol kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 5124854..5169530 | 44676 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 129 a.a. Molecular weight: 14465.40 Da Isoelectric Point: 5.4833
>T284160 WP_014640052.1 NZ_CP127314:c5165569-5165183 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE
Download Length: 387 bp
Antitoxin
Download Length: 170 a.a. Molecular weight: 19559.39 Da Isoelectric Point: 5.3338
>AT284160 WP_024174200.1 NZ_CP127314:c5166108-5165599 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS
Download Length: 510 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|