Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 5007161..5007658 Replicon chromosome
Accession NZ_CP127314
Organism Escherichia coli strain C25

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QRM69_RS24310 Protein ID WP_001173343.1
Coordinates 5007161..5007334 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag QRM69_RS24315 Protein ID WP_001312331.1
Coordinates 5007362..5007658 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM69_RS24300 (5003831) 5003831..5005288 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
QRM69_RS24305 (5005525) 5005525..5007042 + 1518 WP_000003806.1 lysine--tRNA ligase -
QRM69_RS24310 (5007161) 5007161..5007334 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QRM69_RS24315 (5007362) 5007362..5007658 - 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QRM69_RS24320 (5007887) 5007887..5008159 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QRM69_RS24325 (5008171) 5008171..5008401 - 231 WP_000371715.1 4Fe-4S mono-cluster protein YjdI -
QRM69_RS24330 (5008582) 5008582..5010213 + 1632 WP_001216466.1 sensor histidine kinase -
QRM69_RS24335 (5010210) 5010210..5010929 + 720 WP_000611291.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T284159 WP_001173343.1 NZ_CP127314:c5007334-5007161 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT284159 WP_001312331.1 NZ_CP127314:c5007658-5007362 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References