Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4128028..4128646 Replicon chromosome
Accession NZ_CP127314
Organism Escherichia coli strain C25

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QRM69_RS20050 Protein ID WP_001291435.1
Coordinates 4128428..4128646 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QRM69_RS20045 Protein ID WP_000344800.1
Coordinates 4128028..4128402 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM69_RS20035 (4123118) 4123118..4124311 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QRM69_RS20040 (4124334) 4124334..4127483 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QRM69_RS20045 (4128028) 4128028..4128402 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QRM69_RS20050 (4128428) 4128428..4128646 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QRM69_RS20055 (4128819) 4128819..4129370 + 552 WP_000102539.1 maltose O-acetyltransferase -
QRM69_RS20060 (4129486) 4129486..4129956 + 471 WP_001304825.1 YlaC family protein -
QRM69_RS20065 (4130120) 4130120..4131670 + 1551 WP_001528761.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QRM69_RS20070 (4131712) 4131712..4132065 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QRM69_RS20080 (4132444) 4132444..4132755 + 312 WP_000409908.1 MGMT family protein -
QRM69_RS20085 (4132786) 4132786..4133358 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T284153 WP_001291435.1 NZ_CP127314:4128428-4128646 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT284153 WP_000344800.1 NZ_CP127314:4128028-4128402 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References