Detailed information of TA system TA028415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3345301..3345937
• Replicon: chromosome
• Accession: NC_018828
• Organism: Bordetella parapertussis Bpp5

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BN117_RS15885
• Protein ID: WP_164926593.1
• Coordinates: 3345301..3345483 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MKP0
• Locus tag: BN117_RS15890
• Protein ID: WP_015040157.1
• Coordinates: 3345545..3345937 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN117_RS15870	3341485..3342744	-	1260	WP_015040155.1	efflux RND transporter periplasmic adaptor subunit	-
BN117_RS15875	3342997..3343371	-	375	WP_003810336.1	helix-turn-helix domain-containing protein	-
BN117_RS15880	3343533..3344753	+	1221	WP_015039079.1	ISL3-like element IS1001 family transposase	-
BN117_RS15885	3345301..3345483	+	183	WP_164926593.1	type II toxin-antitoxin system HicA family toxin	Toxin
BN117_RS15890	3345545..3345937	+	393	WP_015040157.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BN117_RS15895	3346210..3347121	-	912	WP_015040158.1	LysR family transcriptional regulator	-
BN117_RS15900	3347246..3348220	+	975	Protein_3132	tripartite tricarboxylate transporter substrate binding protein	-
BN117_RS15905	3348255..3348614	+	360	WP_015040159.1	hypothetical protein	-
BN117_RS15910	3348681..3349853	+	1173	WP_010926854.1	thiolase domain-containing protein	-
BN117_RS15915	3349857..3350281	+	425	Protein_3135	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3343533..3344753	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6630.73 Da
• Isoelectric Point: 10.6643

>T28415 WP_164926593.1 NC_018828:3345301-3345483 [Bordetella parapertussis Bpp5]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLDIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T28415 NC_018828:3345301-3345483 [Bordetella parapertussis Bpp5]
ATGGACGGCAAAGAACTGATCAAGCAGCTTGAGCGGTCCGGGTGGACACTGCGGAGCGTTAAGGGCTCCCACCACGTTTT
CGCCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACCCTAAAAAGGATCTCGACATCGGACTACTAAACAGCATCC
TCAAAGCAGCTGGTTTGAAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14087.86 Da
• Isoelectric Point: 4.3596

>AT28415 WP_015040157.1 NC_018828:3345545-3345937 [Bordetella parapertussis Bpp5]
VKYPITIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IANVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT28415 NC_018828:3345545-3345937 [Bordetella parapertussis Bpp5]
GTGAAATATCCCATTACCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTAATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Antitoxin

• AlphaFold DB: K0MKP0