Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1356281..1356935 Replicon chromosome
Accession NZ_CP127314
Organism Escherichia coli strain C25

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QRM69_RS06605 Protein ID WP_000244781.1
Coordinates 1356528..1356935 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QRM69_RS06600 Protein ID WP_000354046.1
Coordinates 1356281..1356547 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM69_RS06580 (1352369) 1352369..1353802 - 1434 WP_001350137.1 6-phospho-beta-glucosidase BglA -
QRM69_RS06585 (1353847) 1353847..1354158 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QRM69_RS06590 (1354322) 1354322..1354981 + 660 WP_000250274.1 hemolysin III family protein -
QRM69_RS06595 (1355058) 1355058..1356038 - 981 WP_000886079.1 tRNA-modifying protein YgfZ -
QRM69_RS06600 (1356281) 1356281..1356547 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QRM69_RS06605 (1356528) 1356528..1356935 + 408 WP_000244781.1 protein YgfX Toxin
QRM69_RS06610 (1356975) 1356975..1357496 - 522 WP_001055874.1 flavodoxin FldB -
QRM69_RS06615 (1357608) 1357608..1358504 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QRM69_RS06620 (1358529) 1358529..1359239 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRM69_RS06625 (1359245) 1359245..1360978 + 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T284139 WP_000244781.1 NZ_CP127314:1356528-1356935 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT284139 WP_000354046.1 NZ_CP127314:1356281-1356547 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References