284128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4342615..4343450 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3U1IU51
Locus tag QRM70_RS21235 Protein ID WP_062878386.1
Coordinates 4342615..4342992 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T3WTI7
Locus tag QRM70_RS21240 Protein ID WP_062878385.1
Coordinates 4343082..4343450 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS21200 (4338229) 4338229..4339167 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
QRM70_RS21210 (4339638) 4339638..4339919 - 282 Protein_4115 DUF4942 domain-containing protein -
QRM70_RS21215 (4340201) 4340201..4341204 - 1004 Protein_4116 IS110-like element ISSfl8 family transposase -
QRM70_RS21220 (4341276) 4341276..4341836 - 561 Protein_4117 DUF4942 domain-containing protein -
QRM70_RS21225 (4341921) 4341921..4342118 - 198 WP_000839249.1 DUF957 domain-containing protein -
QRM70_RS21230 (4342130) 4342130..4342618 - 489 WP_062878387.1 DUF5983 family protein -
QRM70_RS21235 (4342615) 4342615..4342992 - 378 WP_062878386.1 TA system toxin CbtA family protein Toxin
QRM70_RS21240 (4343082) 4343082..4343450 - 369 WP_062878385.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QRM70_RS21245 (4343530) 4343530..4343751 - 222 WP_033878268.1 DUF987 domain-containing protein -
QRM70_RS21250 (4343838) 4343838..4344314 - 477 WP_001186725.1 RadC family protein -
QRM70_RS21255 (4344330) 4344330..4344815 - 486 WP_062887690.1 antirestriction protein -
QRM70_RS21260 (4344870) 4344870..4345688 - 819 Protein_4125 DUF932 domain-containing protein -
QRM70_RS21265 (4345865) 4345865..4346020 - 156 WP_106422060.1 DUF905 family protein -
QRM70_RS21270 (4346099) 4346099..4346554 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG 4332648..4344815 12167
- flank IS/Tn - - 4340746..4341204 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.14 Da        Isoelectric Point: 7.2922

>T284128 WP_062878386.1 NZ_CP127306:c4342992-4342615 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13565.30 Da        Isoelectric Point: 6.7340

>AT284128 WP_062878385.1 NZ_CP127306:c4343450-4343082 [Escherichia coli]
VSDTFSGTTHPNDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLANRAGIRGRFSDADSYHLDQAFPLLMKQLEIMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3U1IU51

Antitoxin

Source ID Structure
AlphaFold DB A0A3T3WTI7

References